Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
about
Regulation of Bim in Health and DiseaseConcomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesisInterspecies Variation in the Functional Consequences of Mutation of Cytochrome cFunctional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivoGenetic control of programmed cell death during animal development.BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool?Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells.Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells.Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis.Requirement of myeloid cell-specific Fas expression for prevention of systemic autoimmunity in mice.Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo.Loss of Bim results in abnormal accumulation of mature CD4-CD8-CD44-CD25- thymocytesThe differential effect of dexamethasone on granulocyte apoptosis involves stabilization of Mcl-1L in neutrophils but not in eosinophils.Targeting ERK1/2-bim signaling cascades by BH3-mimetic ABT-737 as an alternative therapeutic strategy for oral cancer.Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1.Induction of Bim and Bid gene expression during accelerated apoptosis in severe sepsis.Targeting the BCL-2 family in malignancies of germinal centre origin.Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.Expression of cell cycle and apoptosis regulators in thymus and thymic epithelial tumors.Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion.Dying to protect: cell death and the control of T-cell homeostasis.Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis.Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis.Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.Specific requirement for Bax, not Bak, in Myc-induced apoptosis and tumor suppression in vivo.
P2860
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P2860
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
description
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juni 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/06/20)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/06/20)
@nl
наукова стаття, опублікована в червні 2005
@uk
مقالة علمية (نشرت في 20-6-2005)
@ar
name
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@ast
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@en
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@nl
type
label
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@ast
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@en
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@nl
prefLabel
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@ast
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@en
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@nl
P2093
P2860
P50
P921
P356
P1476
Combined loss of proapoptotic ...... sis and in thymocyte apoptosis
@en
P2093
Emily Bickel
Harris Perlman
John C. Scatizzi
Nathaniel J. Brown
P2860
P304
P356
10.1084/JEM.20041484
P407
P577
2005-06-20T00:00:00Z