p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.
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Nodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cellsDeregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerRole of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradationGerm-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humansAutophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast CancerA novel mutation in β integrin reveals an integrin-mediated interaction between the extracellular matrix and cki-1/p27KIP1Tumor suppressor and hepatocellular carcinomaThe gap junction-independent tumor-suppressing effect of connexin 43Animal Models of Chemical Carcinogenesis: Driving Breakthroughs in Cancer Research for 100 YearsMature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma.Co-depletion of cathepsin B and uPAR induces G0/G1 arrest in glioma via FOXO3a mediated p27 upregulation.p27(Kip1) deficiency promotes prostate carcinogenesis but does not affect the efficacy of retinoids in suppressing the neoplastic process.Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.p27 kip1 haplo-insufficiency improves cardiac function in early-stages of myocardial infarction by protecting myocardium and increasing angiogenesis by promoting IKK activationHigh p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycleMAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation.ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cellsA pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionMutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia.Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Hunk is required for HER2/neu-induced mammary tumorigenesis.A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.The prognostic molecular markers in hepatocellular carcinoma.Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical regionInositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells.Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1-deficient mice.Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epitheliumThe many forks in FOXO's road.Relation of overexpression of S phase kinase-associated protein 2 with reduced expression of p27 and PTEN in human gastric carcinoma.Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress.P27kip1 regulates the apoptotic response of gastric epithelial cells to Helicobacter pylori.CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death.p27kip1: a target for tumor therapies?Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype
P2860
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P2860
p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@ast
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@en
type
label
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@ast
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@en
prefLabel
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@ast
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@en
P2093
P356
P1476
p27(Kip1): regulation and func ...... d its misregulation in cancer.
@en
P2093
Philipp-Staheli J
P304
P356
10.1006/EXCR.2000.5143
P407
P577
2001-03-01T00:00:00Z