ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
about
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1Nodal signaling promotes a tumorigenic phenotype in human breast cancerMislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapyBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors"Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin miceSomatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinaseThe yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signalingp27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling.Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactationHaploinsufficient tumor suppressor genes.Oncogenes and tumor suppressor genesA pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionUbiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets.BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis.Hunk is required for HER2/neu-induced mammary tumorigenesis.Regulation of CDK4ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.p27kip1: a target for tumor therapies?Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotypeA new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development.A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation.Tumor suppressor genetics.Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activityThe CDK inhibitors: potential targets for therapeutic stem cell manipulations?Deficiency of the cyclin-dependent kinase inhibitor, CDKN1B, results in overgrowth and neurodevelopmental delayIncreased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1Endocrine dysfunction in p27Kip1 deficient mice and susceptibility to Wnt-1 driven breast cancerDicer1 functions as a haploinsufficient tumor suppressor.The function of p27 KIP1 during tumor development.Cooperative regulation of the cell division cycle by the protein kinases RAF and AKTA critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis.Signaling through cyclin D-dependent kinases.Effect of Oncoxin Oral Solution in HER2-Overexpressing Breast Cancer.Genetics and epigenetics in small intestinal neuroendocrine tumours.Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer.
P2860
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P2860
ErbB2/Neu-induced, cyclin D1-dependent transformation is accelerated in p27-haploinsufficient mammary epithelial cells but impaired in p27-null cells
description
2002 nî lūn-bûn
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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@ast
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@en
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@nl
type
label
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@ast
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@en
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@nl
prefLabel
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@ast
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@en
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@nl
P2093
P2860
P1476
ErbB2/Neu-induced, cyclin D1-d ...... but impaired in p27-null cells
@en
P2093
Anne E G Lenferink
Carlos L Arteaga
Dana M Brantley
Elizabeth Hamilton
L Renee Roebuck
Rebecca S Muraoka
P2860
P304
P356
10.1128/MCB.22.7.2204-2219.2002
P407
P577
2002-04-01T00:00:00Z