Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.
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Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptorOverexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterolRapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.Endoglin is required for myogenic differentiation potential of neural crest stem cellsSmooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressureHypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryOverexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearanceSpatial relational memory requires hippocampal adult neurogenesisEfficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitroIncreased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic miceMultiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice.Apolipoprotein E: from lipid transport to neurobiologyFrom diet to DNA: dietary patterning of gene expression.Experimental and clinical applications of molecular cell biology in nutrition and metabolism.Lowering cholesterol, 1988. Rationale, mechanisms, and means.The familial hypercholesterolemia (FH)-North Karelia mutation of the low density lipoprotein receptor gene deletes seven nucleotides of exon 6 and is a common cause of FH in Finland.Modification of low density lipoprotein by advanced glycation end products contributes to the dyslipidemia of diabetes and renal insufficiency.Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal miceTissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.Recent developments in the treatment of atherosclerosis.Transgenic mouse models of lipoprotein metabolism and atherosclerosisCytoplasmic sequence required for basolateral targeting of LDL receptor in livers of transgenic mice.Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic miceOverexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis.Hepatitis B virus induces expression of cholesterol metabolism-related genes via TLR2 in HepG2 cells.Molecular biology and gene transfer in atherosclerosis in the stenting era.Exploring pathogenetic mechanisms using transgenic animals.Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.Low-density-lipoprotein receptors in different rabbit liver cells.Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice.Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.Hepatic lipid accumulation in apolipoprotein C-I-deficient mice is potentiated by cholesteryl ester transfer protein.Molecular Genetics of Familial Hypercholesterolaemia: Common and Rare Mutations of the Low Density Lipoprotein Receptor Gene
P2860
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P2860
Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.
description
1988 nî lūn-bûn
@nan
1988 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի մարտին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Overexpression of low density ...... rom plasma in transgenic mice.
@ast
Overexpression of low density ...... rom plasma in transgenic mice.
@en
Overexpression of low density lipoprotein
@nl
type
label
Overexpression of low density ...... rom plasma in transgenic mice.
@ast
Overexpression of low density ...... rom plasma in transgenic mice.
@en
Overexpression of low density lipoprotein
@nl
prefLabel
Overexpression of low density ...... rom plasma in transgenic mice.
@ast
Overexpression of low density ...... rom plasma in transgenic mice.
@en
Overexpression of low density lipoprotein
@nl
P2093
P356
P1433
P1476
Overexpression of low density ...... rom plasma in transgenic mice.
@en
P2093
D W Russell
J L Goldstein
R E Hammer
S L Hofmann
P304
P356
10.1126/SCIENCE.3344433
P407
P577
1988-03-01T00:00:00Z