Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
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cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolismcDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brainMolecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteinsRole of LXRs in control of lipogenesisHepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1cSterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolismCrystal structure of Spot 14, a modulator of fatty acid synthesisCharacterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteinsSterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytesSecreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic miceIdentification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating proteinEndocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesityIdentification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoterDifferential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cellsBlasts from the pastRegulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaOverexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisThe blind men 'see' the elephant-the many faces of fatty liver diseaseUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepOccupancy and function of the -150 sterol regulatory element and -65 E-box in nutritional regulation of the fatty acid synthase gene in living animalsHepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient miceCombined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesThe role of glucosamine-induced ER stress in diabetic atherogenesisGenetically modified mouse models for the study of nonalcoholic fatty liver diseaseDual functions of Insig proteins in cholesterol homeostasisDiverse roles of SIRT1 in cancer biology and lipid metabolismLiver steatosis in hepatitis C patientsA duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and menCritical role of PA28 in hepatitis C virus-associated steatogenesis and hepatocarcinogenesisA century of cholesterol and coronaries: from plaques to genes to statinsCo-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 proteinIncreased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the livermTOR signaling in tumorigenesisAssociation between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcriptionDirect interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoterA role for smooth endoplasmic reticulum membrane cholesterol ester in determining the intracellular location and regulation of sterol-regulatory-element-binding protein-2SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevationHomocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathwaysStatin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I
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P2860
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@en
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@nl
type
label
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@en
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@nl
prefLabel
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@en
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@nl
P2093
P2860
P356
P1476
Overproduction of cholesterol ...... expressing truncated SREBP-1a.
@en
P2093
I Shimomura
J D Horton
J L Goldstein
R E Hammer
P2860
P304
P356
10.1172/JCI118951
P407
P577
1996-10-01T00:00:00Z