Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
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Influence of phosphate and phosphoesters on the decomposition pathway of 1,2-bis(methylsulfonyl)-1-(2-chloroethyhydrazine (90CE), the active anticancer moiety generated by Laromustine, KS119, and KS119WInfluence of glutathione and glutathione S-transferases on DNA interstrand cross-link formation by 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine, the active anticancer moiety generated by laromustine.Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.KS900: A hypoxia-directed, reductively activated methylating antitumor prodrug that selectively ablates O(6)-alkylguanine-DNA alkyltransferase in neoplastic cells.A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions.Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase.Chloroethylating and methylating dual function antineoplastic agents display superior cytotoxicity against repair proficient tumor cells.Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines.Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumorsExpression of O(6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue.Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools.The potential of combi-molecules with DNA-damaging function as anticancer agents.Preliminary studies with a new hypoxia-selective cytotoxin, KS119W, in vitro and in vivo.Identification of the Structural Features of Guanine Derivatives as MGMT Inhibitors Using 3D-QSAR Modeling Combined with Molecular Docking.Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage.pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.Theoretical study of methyl group transfer assisted by proton transfer reaction in the N-acylated imidates.Every OGT Is Illuminated … by Fluorescent and Synchrotron Lights.PAM-OBG: A monoamine oxidase B specific prodrug that inhibits MGMT and generates DNA interstrand crosslinks, potentiating temozolomide and chemoradiation therapy in intracranial glioblastoma.
P2860
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P2860
Quantitative relationship between guanine O(6)-alkyl lesions produced by Onrigin™ and tumor resistance by O(6)-alkylguanine-DNA alkyltransferase.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Quantitative relationship between guanine O
@nl
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@ast
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@en
type
label
Quantitative relationship between guanine O
@nl
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@ast
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@en
prefLabel
Quantitative relationship between guanine O
@nl
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@ast
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@en
P2093
P2860
P1476
Quantitative relationship betw ...... lguanine-DNA alkyltransferase.
@en
P2093
Alan C Sartorelli
Kimiko Ishiguro
Krishnamurthy Shyam
Philip G Penketh
Raymond P Baumann
Yong-Lian Zhu
P2860
P304
P356
10.1016/J.BCP.2010.07.022
P407
P577
2010-07-21T00:00:00Z