about
Total synthesis of bryostatin 7 via C-C bond-forming hydrogenationCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisDynamics and Membrane Interactions of Protein Kinase CDesigned, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitroSynthesis of seco-B-ring bryostatin analogue WN-1 via C-C bond-forming hydrogenation: critical contribution of the B-ring in determining bryostatin-like and phorbol 12-myristate 13-acetate-like properties.Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone coreEnantioselective Alcohol C-H Functionalization for Polyketide Construction: Unlocking Redox-Economy and Site-Selectivity for Ideal Chemical Synthesis.Total synthesis of the cyanolide A aglycon.Computer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.Lead Diversification through a Prins-Driven Macrocyclization Strategy: Application to C13-Diversified Bryostatin Analogues.Toward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyGuanidinium-rich, glycerol-derived oligocarbonates: a new class of cell-penetrating molecular transporters that complex, deliver, and release siRNA"Picolog," a synthetically-available bryostatin analog, inhibits growth of MYC-induced lymphoma in vivo.Bi(OTf)3-, TfOH-, and TMSOTf-mediated, one-pot epoxide rearrangement, addition, and intramolecular silyl-modified Sakurai (ISMS) cascade toward dihydropyrans: comparison of catalysts and role of Bi(OTf)3Advances in the synthesis of glycosidic macrolides: clavosolides A-D and cyanolide A.Synthesis of bridged inside-outside bicyclic ethers through oxidative transannular cyclization reactions.Mechanistic and computational studies of exocyclic stereocontrol in the synthesis of bryostatin-like cis-2,6-disubstituted 4-alkylidenetetrahydropyrans by Prins cyclization.Inhibition of Chikungunya Virus-Induced Cell Death by Salicylate-Derived Bryostatin Analogues Provides Additional Evidence for a PKC-Independent Pathway.Toward the Ideal Synthesis and Transformative Therapies: The Roles of Step Economy and Function Oriented Synthesis.Neurotrophic natural products: chemistry and biology.Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition.Toward the ideal synthesis and molecular function through synthesis-informed design.Synthesis and biological activities of simplified analogs of the natural PKC ligands, bryostatin-1 and aplysiatoxin.Considerations of the chemical biology of microbial natural products provide an effective drug discovery strategy.Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity.Promiscuity of a modular polyketide synthase towards natural and non-natural extender units.Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs.A tandem isomerization/prins strategy: iridium(III)/Brønsted acid cooperative catalysisEvaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.Replacement of the Bryostatin A- and B-Pyran Rings With Phenyl Rings Leads to Loss of High Affinity Binding With PKC.Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation: total syntheses of (±)-centrolobine and (+)-decytospolides A and B.A short and flexible route to tetrahydropyran-4-ones via conjugated nitrile oxides cycloaddition and oxa-Michael cyclization: a concise diastereoselective total synthesis of (±)-diospongin A.Scalable synthesis of bryostatin 1 and analogs, adjuvant leads against latent HIV.Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions.Total Synthesis of Bryostatin 8 Using an Organosilane-Based Strategy.Total synthesis of 7-des-O-pivaloyl-7-O-benzylbryostatin 10.Synthetic approaches to the C11-C27 fragments of bryostatins.An iodine catalyzed metal free domino process for the stereoselective synthesis of oxygen bridged bicyclic ethers.The evolution of a stereoselective synthesis of the C1-C16 fragment of bryostatins.Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans
P2860
Q24607710-E14839F8-DCC0-47FF-A1CC-3BDC2C3859D3Q26772873-3E4EF246-2D24-470C-BDAE-58C0677DD7B7Q26799286-787C2341-6EC8-4B88-91DB-B0D36F28DA35Q30558754-BC02EB60-870B-454A-9105-B965F0BEFA95Q34282542-DF666DAA-BB31-4CF4-BE1E-7AB45090A191Q34282624-107AA79B-597A-473F-AA2F-A7EA81FC7EC2Q34523499-BBCB825C-FF2B-42A9-9272-EBF8934E287CQ35097674-3C6E8AC2-BBCE-481D-8001-F2E3093219DBQ35100672-C2101602-FCA9-42DE-8637-C9C0733AF608Q35132573-04AF1896-EE89-4A94-8654-A383EF3DCF39Q35511561-35D2B46C-7713-4E2E-8C17-0E7005F21642Q35535949-DAE31FA3-2B35-48E7-B67A-687EF0A71A1EQ35799776-6A16D253-6BB2-494C-B925-347DA345F33AQ35986497-762CC93A-324F-4F2C-B97E-FA361FDA9E33Q36156057-DB6F041A-6154-4DF1-A239-160F62F7E869Q36400072-091A9A03-E303-427F-ADF8-556BE848372BQ36510954-ACF7050A-024C-4D84-A294-4EA14EDDAB36Q37088206-8DDA3BFD-A4FD-4B35-BC5B-640873BC4C4AQ37095319-25E995E2-8F63-4AD4-BFD3-4CD7993F152CQ37623342-EC26DF6A-585E-4E6A-A1C7-B3849D8BFF08Q38186988-D252FA08-8AA1-4A18-B632-F0605508F106Q38192884-1D37E3BE-81A1-4C61-9B83-9B4071D48C7BQ38200047-C51D1BA7-4118-497A-A7A9-9F9FEEBDA621Q38558457-C252EBE9-03FE-43BB-895B-7AB367204EACQ39349800-8BA31CBE-A795-49EC-8B5B-BEAB1DA7991DQ39417729-A8A65BC9-139E-4D9B-8BDC-60B4B1D8183BQ40256582-4F71066A-5ED7-4817-BFE8-9CB93EF70AEEQ41898587-2B2C06FE-5293-492A-BE30-C7992DA4FC42Q42135531-403BABF0-2163-4BFB-A19A-42DBEF75AF39Q42388442-729DE97E-455E-4F1F-90CE-5AA1DCFAEECCQ44902741-7A443EF0-1DFB-40A7-877B-C9B3F042CAD2Q45123145-179CF4DA-C7BB-4DB5-9A45-41BC5CD7F1B8Q47614932-6A4152C5-BBCA-461A-A6DB-C5DB14C385C8Q48152462-D067B884-FE6D-4037-88CD-D1D9DAD85385Q48168987-D72C9B5F-AD54-42C8-BCFF-444F752FEFF3Q50130105-296EA26B-48D2-4C89-87FA-1D72AE9EE9EDQ50130124-657B30FA-2B3F-4FDD-861D-E98CED1715DDQ50974645-AE919544-E780-4CDB-8A4B-281D56153E22Q52845242-103A2B54-A179-4D39-AA92-C671EFF571B1Q57776726-9905842A-244E-4567-B7FD-1CBC2E81C059
P2860
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Total synthesis of bryostatin 9
@ast
Total synthesis of bryostatin 9
@en
Total synthesis of bryostatin 9
@nl
type
label
Total synthesis of bryostatin 9
@ast
Total synthesis of bryostatin 9
@en
Total synthesis of bryostatin 9
@nl
prefLabel
Total synthesis of bryostatin 9
@ast
Total synthesis of bryostatin 9
@en
Total synthesis of bryostatin 9
@nl
P2860
P356
P1476
Total synthesis of bryostatin 9
@en
P2093
Adam J Schrier
Paul A Wender
P2860
P304
P356
10.1021/JA203034K
P407
P577
2011-05-27T00:00:00Z