A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC
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Postischemic PKC activation rescues retrograde and anterograde long-term memoryTotal synthesis of bryostatin 16 using atom-economical and chemoselective approachesPractical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIVNew Drugs from Marine Organisms in Alzheimer's DiseaseCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisTargeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disordersα-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological ConditionsBryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic strokeProtein kinase C stimulates HuD-mediated mRNA stability and protein expression of neurotrophic factors and enhances dendritic maturation of hippocampal neurons in cultureEfficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder.Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer's Disease Phase IIa and Expanded Access Trials.Total synthesis of bryostatin 16 using a Pd-catalyzed diyne coupling as macrocyclization method and synthesis of C20-epi-bryostatin 7 as a potent anticancer agent.Adrenocortical status predicts the degree of age-related deficits in prefrontal structural plasticity and working memory.Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivityTotal synthesis of bryostatin 9Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brainsComputer-guided design, synthesis, and protein kinase C affinity of a new salicylate-based class of bryostatin analogs.Improved protein kinase C affinity through final step diversification of a simplified salicylate-derived bryostatin analog scaffold.Using the Morris water maze to assess spatial learning and memory in weanling miceToward a biorelevant structure of protein kinase C bound modulators: design, synthesis, and evaluation of labeled bryostatin analogues for analysis with rotational echo double resonance NMR spectroscopyTotal synthesis of bryostatins: the development of methodology for the atom-economic and stereoselective synthesis of the ring C subunit.Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formationBryostatin extends tPA time window to 6 h following middle cerebral artery occlusion in aged female rats.Natural products as a source of Alzheimer's drug leads.Stabilizing dendritic structure as a novel therapeutic approach for epilepsy.A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblastsPropofol and midazolam inhibit conscious memory processes very soon after encoding: an event-related potential study of familiarity and recollection in volunteers.Prins-type macrocyclizations as an efficient ring-closing strategy in natural product synthesis.G Protein-Gated K+ Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning.Calcium, Reactive Oxygen Species, and Synaptic Plasticity.Drebrin a knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex.The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity.Function Oriented Synthesis: Preparation and Initial Biological Evaluation of New A-Ring-Modified Bryologs.Clinical-grade human umbilical cord-derived mesenchymal stem cells reverse cognitive aging via improving synaptic plasticity and endogenous neurogenesis.Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cδ and ε.Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon.Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus.Overexpression of PKMζ alters morphology and function of dendritic spines in cultured cortical neurons.
P2860
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P2860
A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC
description
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2007
@ast
im Dezember 2007 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/12/04)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/12/04)
@nl
наукова стаття, опублікована в грудні 2007
@uk
name
A structural basis for enhance ...... dritic spines regulated by PKC
@ast
A structural basis for enhance ...... dritic spines regulated by PKC
@en
A structural basis for enhance ...... dritic spines regulated by PKC
@nl
type
label
A structural basis for enhance ...... dritic spines regulated by PKC
@ast
A structural basis for enhance ...... dritic spines regulated by PKC
@en
A structural basis for enhance ...... dritic spines regulated by PKC
@nl
prefLabel
A structural basis for enhance ...... dritic spines regulated by PKC
@ast
A structural basis for enhance ...... dritic spines regulated by PKC
@en
A structural basis for enhance ...... dritic spines regulated by PKC
@nl
P2860
P356
P1476
A structural basis for enhance ...... dritic spines regulated by PKC
@en
P2093
Daniel L. Alkon
Jarin Hongpaisan
P2860
P304
19571–19576
P356
10.1073/PNAS.0709311104
P407
P577
2007-12-04T00:00:00Z