The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. - Wikidata - wikimedia - TriplyDB

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

http://www.wikidata.org/entity/Q34190027

about

GAY2911 H-MESO-1 H-MESO-1A HO275 JMN JU77 LO68 Meso-10 Meso-9 Meso37 Meso56 MH MSTO-211H NCI-H2052 NCI-H2373 NCI-H2452 NCI-H28 NO36 O24B OLD1612 ONE58 STY51 SU511 VAMT-1 VGE

P1343

High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus BAP1 is phosphorylated at serine 592 in S-phase following DNA damage Germline BAP1 mutations predispose to malignant mesothelioma DUBbing Cancer: Deubiquitylating Enzymes Involved in Epigenetics, DNA Damage and the Cell Cycle As Therapeutic Targets Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work From human genome to cancer genome: the first decade Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network Personalized oncogenomics: clinical experience with malignant peritoneal mesothelioma using whole genome sequencing.Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors.Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors.The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer Hippo/YAP pathway for targeted therapy Connecting molecular pathways to hereditary cancer risk syndromes Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma Loss of expression of BAP1 is a useful adjunct, which strongly supports the diagnosis of mesothelioma in effusion cytology Recent insights emerging from malignant mesothelioma genome sequencing Mithramycin Depletes Specificity Protein 1 and Activates p53 to Mediate Senescence and Apoptosis of Malignant Pleural Mesothelioma Cells Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction Current issues in malignant pleural mesothelioma evaluation and management High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases BAP1 hereditary cancer predisposition syndrome: a case report and review of literature Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma.A meta-analysis of multiple matched copy number and transcriptomics data sets for inferring gene regulatory relationships.Establishment and mutation analysis of a novel malignant peritoneal mesothelioma cell line, TU-MM-1, using whole genome sequencing.Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines.The biomolecular era for thoracic surgeons: the example of the ESTS Biology Club.Tumors that mimic asbestos-related mesothelioma: time to consider a genetics-based tumor registry?The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex Molecular genetics of clear-cell renal cell carcinoma Whole exome sequencing of an asbestos-induced wild-type murine model of malignant mesothelioma.In vitro experimental models of mesothelioma revisited BAP1, a tumor suppressor gene driving malignant mesothelioma.Targeting the epigenome in malignant pleural mesothelioma

P2860

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P2860

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

http://www.wikidata.org/entity/Q34190027

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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type

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The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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prefLabel

The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

@ast

The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

@en

The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

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Nature Genetics

P1476

The nuclear deubiquitinase BAP ...... alignant pleural mesothelioma.

@en

P2093

Adam Olshen

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Barry S Taylor

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Chris Sander

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Jenette Creaney

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Lu Wang

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Marie Brevet

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Matthew Bott

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Maureen F Zakowski

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Qin Zhou

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Richard A Lake

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P2860

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

Defining the human deubiquitinating enzyme interaction landscape

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1

BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

Frequent mutation of BAP1 in metastasizing uveal melanomas

Somatic mutations affect key pathways in lung adenocarcinoma

BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression

P2888

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668-672

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scholarly article

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10.1038/NG.855

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7

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43

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Valerie W Rusch

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2011-06-05T00:00:00Z

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21642991

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4643098

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