Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).
about
HIV Genome-Wide Protein Associations: a Review of 30 Years of ResearchSurfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI InhibitorsTargeting cyclin-dependent kinases in human cancers: from small molecules to Peptide inhibitorsFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityChemical libraries dedicated to protein-protein interactionsDissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein InterfaceStructure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry InhibitorsHigh-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein InteractionHot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzymeProperty Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNABcL-xL conformational changes upon fragment binding revealed by NMRElectrostatic similarities between protein and small molecule ligands facilitate the design of protein-protein interaction inhibitorsRational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approachStructure-based inhibition of protein-protein interactions.NMR-based analysis of protein-ligand interactions.Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics.Elucidating protein inter- and intramolecular interacting domains using chemical cross-linking and matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometryIn silico identification of an interferon inhibitor.A leap into the chemical space of protein-protein interaction inhibitorsAn integrated fragment based screening approach for the discovery of small molecule modulators of the VWF-GPIbα interaction.Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.Plucking the high hanging fruit: a systematic approach for targeting protein-protein interactionsTIMBAL v2: update of a database holding small molecules modulating protein-protein interactionsComputational analysis of protein-protein interfaces involving an alpha helix: insights for terphenyl-like molecules binding.Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonistTargeting RNA binding proteins involved in neurodegeneration.[Phenotypic screens or one stone to kill two birds: discover the target and its pharmacological regulator].2P2I HUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine.HADDOCK(2P2I): a biophysical model for predicting the binding affinity of protein-protein interaction inhibitors.Resolving hot spots in the C-terminal dimerization domain that determine the stability of the molecular chaperone Hsp90Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.How proteins bind macrocycles.Tampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions.Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists.Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.
P2860
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P2860
Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I).
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Chemical and structural lesson ...... interaction inhibition (2P2I).
@ast
Chemical and structural lesson ...... interaction inhibition (2P2I).
@en
Chemical and structural lesson ...... protein interaction inhibition
@nl
type
label
Chemical and structural lesson ...... interaction inhibition (2P2I).
@ast
Chemical and structural lesson ...... interaction inhibition (2P2I).
@en
Chemical and structural lesson ...... protein interaction inhibition
@nl
prefLabel
Chemical and structural lesson ...... interaction inhibition (2P2I).
@ast
Chemical and structural lesson ...... interaction inhibition (2P2I).
@en
Chemical and structural lesson ...... protein interaction inhibition
@nl
P1476
Chemical and structural lesson ...... interaction inhibition (2P2I).
@en
P2093
Philippe Roche
P304
P356
10.1016/J.CBPA.2011.05.024
P577
2011-06-22T00:00:00Z