Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.
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Lipid free apolipoprotein E binds to the class B Type I scavenger receptor I (SR-BI) and enhances cholesteryl ester uptake from lipoproteinsBiophysical analysis of apolipoprotein E3 variants linked with development of type III hyperlipoproteinemiaSwapping the N- and C-terminal domains of human apolipoprotein E3 and AI reveals insights into their structure/activity relationshipAnti-inflammatory and cholesterol-reducing properties of apolipoprotein mimetics: a reviewMacrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe miceApolipoprotein E: from lipid transport to neurobiologyThe relative atherogenicity of VLDL and LDL is dependent on the topographic site.Acrolein modification impairs key functional features of rat apolipoprotein E: identification of modified sites by mass spectrometry.Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null miceApolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice.Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophagesThermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathyLipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasmaVPO1 mediates ApoE oxidation and impairs the clearance of plasma lipids.ApoE genotype, cardiovascular risk and responsiveness to dietary fat manipulation.Residues Leu261, Trp264, and Phe265 account for apolipoprotein E-induced dyslipidemia and affect the formation of apolipoprotein E-containing high-density lipoprotein.Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophagesSuppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.Mechanisms of obesity and related pathologies: role of apolipoprotein E in the development of obesity.Role of apolipoprotein E genotype in coronary artery disease.Apolipoprotein E4 in macrophages enhances atherogenesis in a low density lipoprotein receptor-dependent mannerImpaired secretion of apolipoprotein E2 from macrophages.Molecular biology and gene transfer in atherosclerosis in the stenting era.Reconstituted discoidal ApoE-phospholipid particles are ligands for the scavenger receptor BI. The amino-terminal 1-165 domain of ApoE suffices for receptor binding.Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease.Lipoprotein lipase reduces secretion of apolipoprotein E from macrophages.Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT.Regulated expression of apolipoprotein E by human retinal pigment epithelial cells.Domains of apolipoprotein E contributing to triglyceride and cholesterol homeostasis in vivo. Carboxyl-terminal region 203-299 promotes hepatic very low density lipoprotein-triglyceride secretion.Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.A protective role for kidney apolipoprotein E. Regulation of mesangial cell proliferation and matrix expansion.Apolipoprotein E binding to low density lipoprotein receptor-related protein-1 inhibits cell migration via activation of cAMP-dependent protein kinase A.Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia.Examination of lipid-bound conformation of apolipoprotein E4 by pyrene excimer fluorescence.A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E.The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.Perlecan mediates the antiproliferative effect of apolipoprotein E on smooth muscle cells. An underlying mechanism for the modulation of smooth muscle cell growth?
P2860
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P2860
Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.
description
1995 nî lūn-bûn
@nan
1995 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@ast
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@en
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@nl
type
label
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@ast
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@en
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@nl
prefLabel
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@ast
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@en
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@nl
P2093
P2860
P356
P1476
Inhibition of diet-induced ath ...... rotein E in the arterial wall.
@en
P2093
P2860
P304
P356
10.1172/JCI117687
P407
P577
1995-02-01T00:00:00Z