Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits
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Two adjacent domains (141-150 and 151-160) of apoE covalently linked to a class A amphipathic helical peptide exhibit opposite atherogenic effects.Anti-inflammatory and recycling properties of an apolipoprotein mimetic peptide, Ac-hE18A-NH(2)Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice.Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigreeInhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.Oral administration of L-mR18L, a single domain cationic amphipathic helical peptide, inhibits lesion formation in ApoE null mice.A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.Novel method for reducing plasma cholesterol: a ligand replacement therapy.Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null miceA 10-bp deletion in the apolipoprotein epsilon gene causing apolipoprotein E deficiency and severe type III hyperlipoproteinemia.Apolipoprotein E mimetic is more effective than apolipoprotein A-I mimetic in reducing lesion formation in older female apo E null mice.Recent developments in the treatment of atherosclerosis.Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.Tibolone inhibits aortic atherosclerotic lesionformation in oophorectomized cholesterol-fed rabbits.An apolipoprotein E synthetic peptide targets to lipoproteins in plasma and mediates both cellular lipoprotein interactions in vitro and acute clearance of cholesterol-rich lipoproteins in vivo.Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.Apolipoprotein E mimetics and cholesterol-lowering properties.Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein.Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic miceLipolysis exposes unreactive endogenous apolipoprotein E-3 in human and rat plasma very low density lipoprotein.Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.Recognition of chylomicron remnants and beta-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver alpha 2-macroglobulin-recognition site.Atherogenic remnant lipoproteins: role for proteoglycans in trapping, transferring, and internalizing.A novel endothelial cell-based gene therapy platform for the in vivo delivery of apolipoprotein E.Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by intramuscular injection of plasmid DNA.Chylomicron metabolism in normal, cholesterol-fed, and Watanabe heritable hyperlipidemic rabbits. Saturation of the sequestration step of the remnant clearance pathway.
P2860
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P2860
Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits
description
1989 nî lūn-bûn
@nan
1989 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年学术文章
@wuu
1989年学术文章
@zh-cn
1989年学术文章
@zh-hans
1989年学术文章
@zh-my
1989年学术文章
@zh-sg
1989年學術文章
@yue
name
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@ast
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@en
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@nl
type
label
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@ast
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@en
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@nl
prefLabel
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@ast
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@en
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@nl
P2093
P2860
P356
P1476
Intravenous infusion of apolip ...... plasma lipoproteins in rabbits
@en
P2093
B Greenman
K H Weisgraber
M M Hussain
R W Mahley
P2860
P304
P356
10.1172/JCI114126
P407
P577
1989-06-01T00:00:00Z