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Neuronal life and death: an essential role for the p53 family.

Neuronal life and death: an essential role for the p53 family.

http://www.wikidata.org/entity/Q34201997

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Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons Cdk5 phosphorylates p53 and regulates its activity N-methyl-N-nitrosourea-induced retinal degeneration in mice is independent of the p53 gene Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration.Cell death mechanisms in neurodegeneration.Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3 The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain.The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration Multiple transcription factor families regulate axon growth and regeneration Cell cycle molecules and vertebrate neuron death: E2F at the hub.Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression DNA damage responses in neural cells: Focus on the telomere αNAC inhibition of the FADD-JNK axis plays anti-apoptotic role in multiple cancer cells Ageing and neuronal vulnerability.Regulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34a Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression The p53 family in nervous system development and disease.Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.Metallo-complex activation of neuroprotective signalling pathways as a therapeutic treatment for Alzheimer's disease.Apoptotic cell death in neuroblastoma.p53, a pivotal effector of a functional cross-talk linking presenilins and Pen-2.Tumor suppressive pathways in the control of neurogenesis.Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage.Astroglial U87 Cells Protect Neuronal SH-SY5Y Cells from Indirect Effect of Radiation by Reducing DNA Damage and Inhibiting Fas Mediated Apoptotic Pathway in Coculture System.Neuroprotective effects of luteolin against apoptosis induced by 6-hydroxydopamine on rat pheochromocytoma PC12 cells.Multiple molecular pathways are involved in the neuroprotection of GDNF against proteasome inhibitor induced dopamine neuron degeneration in vivo.The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.Nerve growth factor withdrawal-mediated apoptosis in naive and differentiated PC12 cells through p53/caspase-3-dependent and -independent pathways.Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent.Regulation of neuronal P53 activity by CXCR 4.Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal.

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P2860

Neuronal life and death: an essential role for the p53 family.

http://www.wikidata.org/entity/Q34201997

description

2000 nî lūn-bûn

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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Neuronal life and death: an essential role for the p53 family.

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Cell Death & Differentiation

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Miller FD

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Pozniak CD

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Walsh GS

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P2860

Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice

Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

Neurotrophin signal transduction in the nervous system.

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

An anti-apoptotic role for the p53 family member, p73, during developmental neuron death

Sympathetic neuron survival and proliferation are prolonged by loss of p53 and neurofibromin

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10.1038/SJ.CDD.4400736

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10

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