Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. - Wikidata - wikimedia - TriplyDB

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

http://www.wikidata.org/entity/Q34214364

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Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase Asparagine endopeptidase controls anti-influenza virus immune responses through TLR7 activation IrAE – An asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage Biochemical, transcriptomic and proteomic analyses of digestion in the scorpion Tityus serrulatus: insights into function and evolution of digestion in an ancient arthropod Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain.Blastocystis legumain is localized on the cell surface, and specific inhibition of its activity implicates a pro-survival role for the enzyme.The biology of human lymphoid malignancies revealed by gene expression profiling.Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.Structural basis of reduction-dependent activation of human cystatin F.Asparagine endopeptidase is an innovative therapeutic target for neurodegenerative diseases.Nuclear legumain activity in colorectal cancer.An evolutionary analysis of antigen processing and presentation across different timescales reveals pervasive selection.Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia.Functional imaging of legumain in cancer using a new quenched activity-based probe Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.Asparaginyl endopeptidase: case history of a class II MHC compartment protease.Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase Cathepsin G: roles in antigen presentation and beyond.Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease.Proteolysis mediated by cysteine cathepsins and legumain-recent advances and cell biological challenges.Comparative structural analysis of the caspase family with other clan CD cysteine peptidases.Tau and neurodegenerative disease: the story so far.Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis.Internalization of exogenous cystatin F supresses cysteine proteases and induces the accumulation of single-chain cathepsin L by multiple mechanisms.Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease.The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro.Reconstruction of a pathway of antigen processing and class II MHC peptide capture.Activation of legumain involves proteolytic and conformational events, resulting in a context- and substrate-dependent activity profile.Protease activity of legumain is inhibited by an increase of cystatin E/M in the DJ-1-knockout mouse spleen, cerebrum and heart.Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.GARP: a key receptor controlling FOXP3 in human regulatory T cells.The asparaginyl endopeptidase legumain after experimental stroke.The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site

P2860

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P2860

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

http://www.wikidata.org/entity/Q34214364

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

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name

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@ast

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@en

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@nl

type

label

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@ast

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@en

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@nl

prefLabel

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@ast

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@en

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo.

@en

P2093

Antony N Antoniou

http://www.w3.org/2001/XMLSchema#string

Colin Watts

http://www.w3.org/2001/XMLSchema#string

Daniela Mazzeo

http://www.w3.org/2001/XMLSchema#string

Dongtao Ni Li

http://www.w3.org/2001/XMLSchema#string

Stephen P Matthews

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P2860

Regulation of human separase by securin binding and autocleavage

Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase

Activation of human prolegumain by cleavage at a C-terminal asparagine residue

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion

Crystal structure of the wild-type human procathepsin B at 2.5 A resolution reveals the native active site of a papain-like cysteine protease zymogen

The crystal structure of human procathepsin K

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast.

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

Autocatalytic processing of recombinant human procathepsin L. Contribution of both intermolecular and unimolecular events in the processing of procathepsin L in vitro

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38980-38990

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scholarly article

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10.1074/JBC.M305930200

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P407

P433

40

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P478

278

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P577

2003-07-14T00:00:00Z

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P5875

10661455

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P698

12860980

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