Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes
about
Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applicationsSPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humansStructure activity relationship of dendrimer microbicides with dual action antiviral activityClinical Translation of Nanomedicine.A review of current intravaginal drug delivery approaches employed for the prophylaxis of HIV/AIDS and prevention of sexually transmitted infectionsAntibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groupsVaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmissionTransport and biodistribution of dendrimers across human fetal membranes: implications for intravaginal administration of dendrimer-drug conjugates.Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection.Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate modelPhase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)Virucidal activity of the dendrimer microbicide SPL7013 against HIV-1.A potent combination microbicide that targets SHIV-RT, HSV-2 and HPVSemen enhances HIV infectivity and impairs the antiviral efficacy of microbicides.Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture.Polymeric drugs: Advances in the development of pharmacologically active polymers.Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: formulation and in vitro and in vivo evaluationAmphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo.Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semenExploiting herpes simplex virus entry for novel therapeutics.A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.VivaGel (SPL7013 Gel): a candidate dendrimer--microbicide for the prevention of HIV and HSV infectionVaginal microbicides and the prevention of HIV transmissionA randomized controlled trial of the safety of candidate microbicide SPL7013 gel when applied to the penis.Enhancement of human immunodeficiency virus type 1 replication is not intrinsic to all polyanion-based microbicides.Formulating a sulfonated antiviral dendrimer in a vaginal microbicidal gel having dual mechanisms of actionIn vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmissionDendrimers as therapeutic agents: a systematic review.Dendrimers--revolutionary drugs for infectious diseases.Dendrimers as potential therapeutic tools in HIV inhibition.Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections.Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers.Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials.Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfateTransition-Metal Complexes Based on a Sulfonate-Containing N-Donor Ligand and Their Use as HIV Antiviral AgentsUnexpected Biological Applications of Dendrimers and Specific Multivalency Activities
P2860
Q26771189-FCD2A63D-6F83-4850-BE01-22B9EC91FC3FQ28740364-EAFAFB81-2E0C-4895-A39E-F880A3A8C491Q28749596-CC4CC4F1-FDAB-49D9-80D9-97866449C16EQ30355939-2EC0A71B-CF4B-4339-9089-2248BA3870F9Q30369008-DA162FE8-BC4C-4DE8-BA37-B1C99E67ABB9Q30831776-93DF0637-678F-411D-B76F-CEF8FA44554CQ33245411-1EAFEAC0-2184-44C9-B3AA-D8B6641CEC0EQ33896898-D1D07DFC-1472-4AB1-9763-B9E472D40A40Q34495644-19A5C045-27D7-4B73-BAD5-30CD4A1700A6Q34648571-1061D53B-5BED-4317-9712-2F221A18EB0BQ35012567-F14AC914-A098-44C4-922E-1036F25622E6Q35045703-177F2AB6-F5CB-4FC3-A5B6-84D4880EC51DQ35150470-B7703C37-19F8-4721-AF08-F0C92108ACD6Q35213456-29274839-619F-4791-9CFF-4D88D957278AQ35759112-685A9016-3D17-469E-A854-FE1529726DF4Q36307604-FE68F475-258C-49E0-90C1-72F6119AE5E2Q36566183-2C8D8F8C-5D85-4DBB-97E3-40544277283FQ36804032-0F82DE31-B895-43A1-99E3-9BF8BF98AF40Q36967950-11F6086C-4F19-4748-8011-03176D50FD8AQ37030702-51DF0CA0-218E-4D8B-A392-18F59349F1E6Q37036620-86582934-39F2-4B11-AB1B-6FB02B0BD4EEQ37059892-C0B28781-7096-4E53-806E-426BD089BA87Q37063819-B3587B11-1333-4FBC-8FF3-F54FBE6F3215Q37187788-F16EF01D-167C-4BFF-9137-81552B90A951Q37274721-16358112-EE06-44C9-8054-C5E429318B9DQ37374013-EABCEDC0-3100-475E-B568-2B28BC977A91Q37568492-D5179E4B-1682-4E0D-B4E7-CDDBB1314B12Q37585659-C33FDDB4-2058-4103-AD5C-3C1AD84EC007Q38023801-0B0A74E6-7573-4FF4-B9FB-7785D84CF8C4Q38123954-69C45838-B179-4595-A2CA-81CA7AADAD01Q38925952-F1EC626B-64A3-4E96-826C-EED15C3682C4Q39541397-66AAD85C-4190-49E7-8550-B0A11D1C4BADQ49963085-10EB28CB-FD06-4EE2-977F-7932E58124DFQ57079901-DECE5471-1A44-467B-B998-8DC251FC63F4Q57079987-B4235CD4-8537-4C66-A15D-B4C3CAE49A5DQ57340548-F88A62AA-5A63-4A4D-BE0F-8B5272129A8F
P2860
Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Evaluations of unformulated an ...... a pig models of genital herpes
@ast
Evaluations of unformulated an ...... a pig models of genital herpes
@en
Evaluations of unformulated an ...... a pig models of genital herpes
@nl
type
label
Evaluations of unformulated an ...... a pig models of genital herpes
@ast
Evaluations of unformulated an ...... a pig models of genital herpes
@en
Evaluations of unformulated an ...... a pig models of genital herpes
@nl
prefLabel
Evaluations of unformulated an ...... a pig models of genital herpes
@ast
Evaluations of unformulated an ...... a pig models of genital herpes
@en
Evaluations of unformulated an ...... a pig models of genital herpes
@nl
P2093
P2860
P1476
Evaluations of unformulated an ...... a pig models of genital herpes
@en
P2093
B Matthews
D I Bernstein
L R Stanberry
R J Mumper
T McCarthy
P2860
P304
P356
10.1128/AAC.47.12.3784-3788.2003
P407
P577
2003-12-01T00:00:00Z