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CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffoldsStructural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantumStructural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterolAntitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite GrowthAntifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1Complexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerStructural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its InhibitionGenetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruziTargeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylaseSterol biosynthesis is required for heat resistance but not extracellular survival in leishmaniaComputational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug DiscoverySterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasisFungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens.Polymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.Clotrimazole as a potent agent for treating the oomycete fish pathogen Saprolegnia parasitica through inhibition of sterol 14α-demethylase (CYP51)Sterols in spermatogenesis and sperm maturation.Structural differences between soluble and membrane bound cytochrome P450sSequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibitionHeterologous expression of the Monilinia fructicola CYP51 (MfCYP51) gene in Pichia pastoris confirms the mode of action of the novel fungicide, SYP-Z048.Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51)Azole Antifungal Sensitivity of Sterol 14α-Demethylase (CYP51) and CYP5218 from Malassezia globosaStructure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs.The Tetrazole VT-1161 Is a Potent Inhibitor of Trichophyton rubrum through Its Inhibition of T. rubrum CYP51.Targeting Trypanosoma cruzi sterol 14α-demethylase (CYP51)Localization and substrate selectivity of sea urchin multidrug (MDR) efflux transportersClinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus.Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function.Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1.Reduced white matter MRI transverse relaxation rate in cognitively normal H63D-HFE human carriers and H67D-HFE mice.Investigations of heme ligation and ligand switching in cytochromes p450 and p420.Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.Novel mutations in CYP51B from Penicillium digitatum involved in prochloraz resistance.Shape and pharmacophore-based virtual screening to identify potential cytochrome P450 sterol 14α-demethylase inhibitors.The binding mechanism between azoles and FgCYP51B, sterol 14α-demethylase of Fusarium graminearum.
P2860
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P2860
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Structural basis for conservation in the CYP51 family.
@ast
Structural basis for conservation in the CYP51 family.
@en
Structural basis for conservation in the CYP51 family.
@nl
type
label
Structural basis for conservation in the CYP51 family.
@ast
Structural basis for conservation in the CYP51 family.
@en
Structural basis for conservation in the CYP51 family.
@nl
prefLabel
Structural basis for conservation in the CYP51 family.
@ast
Structural basis for conservation in the CYP51 family.
@en
Structural basis for conservation in the CYP51 family.
@nl
P2860
P1476
Structural basis for conservation in the CYP51 family.
@en
P2093
Galina I Lepesheva
Michael R Waterman
P2860
P356
10.1016/J.BBAPAP.2010.06.006
P407
P577
2010-06-11T00:00:00Z