In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
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Trypanocidal activity of marine natural productsComplexes of Trypanosoma cruzi Sterol 14 -Demethylase (CYP51) with Two Pyridine-based Drug Candidates for Chagas Disease: STRUCTURAL BASIS FOR PATHOGEN SELECTIVITYStructural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its InhibitionSterol biosynthesis is required for heat resistance but not extracellular survival in leishmaniaMachine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug DiscoveryErgosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria.In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruziIn vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi.Sequence variation in CYP51A from the Y strain of Trypanosoma cruzi alters its sensitivity to inhibitionDrug strategies targeting CYP51 in neglected tropical diseasesBinding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs.Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection.Clinical Candidate VT-1161's Antiparasitic Effect In Vitro, Activity in a Murine Model of Chagas Disease, and Structural Characterization in Complex with the Target Enzyme CYP51 from Trypanosoma cruzi.Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?Two analogues of fenarimol show curative activity in an experimental model of Chagas disease.Potential new clinical therapies for Chagas disease.Therapeutical approaches under investigation for treatment of Chagas disease.Chagas disease drug discovery: toward a new era.Assessing anti-T. cruzi candidates in vitro for sterile cidality.In vitro and in vivo activity of the chloroaryl-substituted imidazole viniconazole against Trypanosoma cruzi.Antitrypanosomal Activity of Sterol 14α-Demethylase (CYP51) Inhibitors VNI and VFV in the Swiss Mouse Models of Chagas Disease Induced by the Trypanosoma cruzi Y Strain.A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors.Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.Repurposing Strategy of Atorvastatin against Trypanosoma cruzi: Monotherapy and Combined Therapy with Benznidazole Exhibit Synergistic Trypanocidal Activity
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P2860
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 June 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
In vitro and in vivo studies o ...... strains of Trypanosoma cruzi.
@en
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase
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type
label
In vitro and in vivo studies o ...... strains of Trypanosoma cruzi.
@en
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase
@nl
prefLabel
In vitro and in vivo studies o ...... strains of Trypanosoma cruzi.
@en
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase
@nl
P2093
P2860
P356
P1476
In vitro and in vivo studies o ...... t strains of Trypanosoma cruzi
@en
P2093
Beatriz Philot Pavão
Claudia Alessandra Fortes Aiub
Cristiane França da Silva
Denise da Gama Jaen Batista
Elen Mello de Souza
Galina I Lepesheva
Gary Sulikowski
Jessica Lionel
Julianna Siciliano Araújo
Kwangho Kim
P2860
P304
P356
10.1128/AAC.00070-13
P407
P577
2013-06-17T00:00:00Z