Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
about
Out of balance: R-loops in human diseaseMutations disrupting histone methylation have different effects on replication timing in S. pombe centromereA SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damageTranscription Blockage Leads to New BeginningsCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisBreaking bad: R-loops and genome integrityReplication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stabilityMolecular traffic jams on DNASources of DNA double-strand breaks and models of recombinational DNA repairFanconi anemia and the cell cycle: new perspectives on aneuploidySenataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage ResponseThe Causes and Consequences of Topological Stress during DNA ReplicationTranscriptional termination in mammals: Stopping the RNA polymerase II juggernautSnaps and mends: DNA breaks and chromosomal translocationsReplication stress in Mammalian cells and its consequences for mitosisRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeGenetic instability in budding and fission yeast-sources and mechanismsInterference in DNA replication can cause mitotic chromosomal breakage unassociated with double-strand breaksMammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrityTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionEnvironmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells.DNA secondary structure at chromosomal fragile sites in human disease.Processing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.Replication fork stability is essential for the maintenance of centromere integrity in the absence of heterochromatinPapillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome.High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesisSsb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.Mechanisms of genome instability induced by RNA-processing defects.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expressionRoad rules for traffic on DNA-systematic analysis of transcriptional roadblocking in vivo.Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chipAre common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?Rescue from replication stress during mitosis.DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomesThe AID-induced DNA damage response in chromatin.Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instabilityDNA topoisomerases participate in fragility of the oncogene RET.Fragile site instability in Saccharomyces cerevisiae causes loss of heterozygosity by mitotic crossovers and break-induced replication.
P2860
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P2860
Collisions between replication and transcription complexes cause common fragile site instability at the longest human genes.
description
2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Collisions between replication ...... ty at the longest human genes.
@ast
Collisions between replication ...... ty at the longest human genes.
@en
Collisions between replication ...... ty at the longest human genes.
@nl
type
label
Collisions between replication ...... ty at the longest human genes.
@ast
Collisions between replication ...... ty at the longest human genes.
@en
Collisions between replication ...... ty at the longest human genes.
@nl
prefLabel
Collisions between replication ...... ty at the longest human genes.
@ast
Collisions between replication ...... ty at the longest human genes.
@en
Collisions between replication ...... ty at the longest human genes.
@nl
P1433
P1476
Collisions between replication ...... ty at the longest human genes.
@en
P2093
Anne Helmrich
P304
P356
10.1016/J.MOLCEL.2011.10.013
P577
2011-12-01T00:00:00Z