Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. - Wikidata - wikimedia - TriplyDB

Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

http://www.wikidata.org/entity/Q34243816

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Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression Targeting SH2 domains in breast cancer Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth Therapeutic modulators of STAT signalling for human diseases Development, characterization, and reversal of acquired resistance to the MEK1 inhibitor selumetinib (AZD6244) in an in vivo model of childhood astrocytoma.Initial solid tumor testing (stage 1) of AZD1480, an inhibitor of Janus kinases 1 and 2 by the pediatric preclinical testing program.RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration.Characterization of STAT3 expression, signaling and inhibition in feline oral squamous cell carcinoma Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer.Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.Gastric tumour-derived ANGPT2 regulation by DARPP-32 promotes angiogenesis Melittin derived peptides for nanoparticle based siRNA transfection.The Bromodomain BET Inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma ΔNp63 promotes pediatric neuroblastoma and osteosarcoma by regulating tumor angiogenesis STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia.Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma.Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients.Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines.Protective effect of suppressing STAT3 activity in LPS-induced acute lung injury Myeloperoxidase oxidized LDL interferes with endothelial cell motility through miR-22 and heme oxygenase 1 induction: possible involvement in reendothelialization of vascular injuries.A novel small inhibitor, LLL12, targets STAT3 in non-small cell lung cancer and

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P2860

Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

http://www.wikidata.org/entity/Q34243816

description

2012 nî lūn-bûn

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2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2012 թվականի ապրիլին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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type

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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prefLabel

Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

@nl

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JOURNAL.PONE.0035513

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Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12.

@en

P2093

Chenglong Li

http://www.w3.org/2001/XMLSchema#string

Cheryl A London

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Duane Oswald

http://www.w3.org/2001/XMLSchema#string

Hemant K Bid

http://www.w3.org/2001/XMLSchema#string

Jiayuh Lin

http://www.w3.org/2001/XMLSchema#string

Peter J Houghton

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P2860

A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells

Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells

Characterization of STAT3 activation and expression in canine and human osteosarcoma.

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells.

A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells.

Molecular characterization of the pediatric preclinical testing panel

Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.

STAT3: a critical transcription activator in angiogenesis.

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scholarly article

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10.1371/JOURNAL.PONE.0035513

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3328460

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