PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
about
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutationThe RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationMicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocationMicroRNA-155 is a negative regulator of activation-induced cytidine deaminaseMultiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them allRegulation of Aicda expression and AID activityTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesThe splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNACyclic-AMP-dependent protein kinase A regulates apoptosis by stabilizing the BH3-only protein BimThe interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombinationTemporal regulation of Ig gene diversification revealed by single-cell imaging.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceT cells contain an RNase-insensitive inhibitor of APOBEC3G deaminase activity.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytesCandidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroBinding of AID to DNA does not correlate with mutator activity.Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in miceRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma.Cyclin D3 is selectively required for proliferative expansion of germinal center B cells.Targeting of somatic hypermutation.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylationComplex regulation and function of activation-induced cytidine deaminase.APOBEC deaminases-mutases with defensive roles for immunity.Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination.Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.Generation and characterization of induced pluripotent stem cells from Aid-deficient mice.Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.Parp3 negatively regulates immunoglobulin class switch recombination.Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.
P2860
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P2860
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells
description
2005 nî lūn-bûn
@nan
2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@ast
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@en
PKA-mediated phosphorylation regulates the function of activation-induced deaminase
@nl
type
label
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@ast
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@en
PKA-mediated phosphorylation regulates the function of activation-induced deaminase
@nl
prefLabel
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@ast
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@en
PKA-mediated phosphorylation regulates the function of activation-induced deaminase
@nl
P2093
P2860
P356
P1476
PKA-mediated phosphorylation r ...... ced deaminase (AID) in B cells
@en
P2093
Riccardo Dalla-Favera
Yasuyuki Kitaura
P2860
P304
P356
10.1073/PNAS.0509969103
P407
P577
2005-12-30T00:00:00Z