Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
about
A camelid anti-PrP antibody abrogates PrP replication in prion-permissive neuroblastoma cell linesTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesSustained translational repression by eIF2α-P mediates prion neurodegenerationLentivector-mediated RNAi efficiently suppresses prion protein and prolongs survival of scrapie-infected miceInsights into Mechanisms of Chronic NeurodegenerationUnfolded Protein Response and Macroautophagy in Alzheimer's, Parkinson's and Prion DiseasesPrion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage responseThe role of ALFY in selective autophagyHijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearanceInsoluble cellular prion protein and its association with prion and Alzheimer diseasesThe strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of diseaseEfficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brainCrystal structure of human prion protein bound to a therapeutic antibodyDifferent 3D domain-swapped oligomeric cyanovirin-N structures suggest trapped folding intermediatesThe toxicity of antiprion antibodies is mediated by the flexible tail of the prion proteinReview: Modulating the unfolded protein response to prevent neurodegeneration and enhance memoryAlzheimer's disease and prion proteinOral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected miceAntihypertensive drug guanabenz is active in vivo against both yeast and mammalian prionsIn vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoformsMammalian prion protein suppresses Bax-induced cell death in yeastMemory impairment in transgenic Alzheimer mice requires cellular prion protein.Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.Cytoplasmic prion protein induces forebrain neurotoxicityGetting a grip on prions: oligomers, amyloids, and pathological membrane interactions.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websRBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets.Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice.Prion formation, but not clearance, is supported by protein misfolding cyclic amplification.Scrapie affects the maturation cycle and immune complex trapping by follicular dendritic cells in miceFunctional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationIn vitro and in vivo neurotoxicity of prion protein oligomers.Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genesEndoplasmic reticulum stress, PrP trafficking, and neurodegeneration.Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cellsInoculation of scrapie with the self-assembling RADA-peptide disrupts prion accumulation and extends hamster survival.Fishing for prion protein function
P2860
Q21562652-5ED1AEB8-6C71-461F-9379-206168FE3CCBQ24289511-F627DEC4-8D2E-464E-8031-172BB920DA44Q24602153-FD98F454-5A90-4BD3-8ED4-11CE74C42F72Q24673105-7D493122-6A3D-4C10-9B80-8E1C48ABF22DQ26771732-FA017375-E764-470D-9D3E-514143BC7FE5Q26773443-50D204BD-4C60-46FD-8477-9BDD732E55C6Q26797972-0F6E90ED-3B71-4BCE-8D64-6B992922895EQ26828736-458E2BC5-C9A1-4B77-8A3C-12F3C5D71F33Q27009790-D9F37273-1996-44E1-BB5F-B012F266AE71Q27012706-798AA19E-9534-4A4C-BA45-1C9109609887Q27312083-1EFF36A5-55A3-47F4-8AE2-671A23CF0B31Q27320015-5E913FD8-84D2-4BEA-AC3C-0178F4E4F139Q27653698-6FFC86F8-0D11-44A6-9EDA-E98A63E3D2C6Q27677513-ECFA7650-9895-4C63-9CFC-ECD15FA7466DQ27685314-8071444C-C05F-4757-B494-7624037BE293Q28081526-0B33060E-CDA9-4B45-B5C9-5BF04DB70993Q28250275-66761235-318B-4E13-A4BF-091C6C8B4C7CQ28300013-E6C82900-2BDC-4035-829A-18A66A5C09DEQ28472560-84F4F061-6092-4102-8CCE-1FCC4C2A8692Q28475550-175EF697-019C-4B0A-B0E5-B624F3E041A4Q28594938-70F549E8-4AFE-4BD5-8CDF-827127202399Q30032301-F87DF8F8-EA8D-4460-835B-78CF7F35DD59Q30482741-1FA20D95-1CEF-48EE-AB8B-DCA69CD87579Q30483457-5A915F95-7F26-4FD7-86BE-921E0BFAB1D7Q30483989-3CB0072B-8BF1-4CE9-872F-F2D9A0C6778BQ30488090-7C5E791C-E738-4D4B-851B-B493C9A0CF2AQ30492360-000062EC-CCFB-466C-A953-6F9D0A0A35C9Q30570683-68A919E3-13BB-4D93-83C0-2207244AC406Q30621066-AF41A1BF-D816-4B24-B2A7-468C8EAF49ADQ30784753-9334DC96-F1D3-4D33-BBDB-320DAE990638Q30853501-21D6F007-4F87-44DE-A7A5-F39C36CC10CCQ30875331-CB645E64-8213-4E06-A1BD-3CEB3A7191FDQ30973674-07A6C3EB-4664-49B4-B43C-841A83968712Q33289413-78D97B5E-8FE8-410B-B214-AB8A34C75470Q33296885-6F9F5BAE-C504-4958-A05C-9ED171B8D525Q33322227-F0A529FD-51DD-4155-BA2E-03D80203A27FQ33346044-E798584A-F31A-45FA-B3F1-E91AD9459899Q33369210-879AD7EB-881F-4956-8596-4A0C81CE8D9BQ33408553-137C236B-24FE-4B3B-9926-6041A10838A7Q33425420-A8F15A36-D0D6-4EBE-9691-DAAA8EAE59BF
P2860
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@ast
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@en
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@nl
type
label
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@ast
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@en
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@nl
prefLabel
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@ast
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@en
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
@nl
P2093
P356
P1433
P1476
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
@en
P2093
Andrew Dickinson
Jacqueline Linehan
John Collinge
Peter-Christian Klöhn
Sebastian Brandner
P304
P356
10.1126/SCIENCE.1090187
P407
P577
2003-10-01T00:00:00Z