Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. - Wikidata - wikimedia - TriplyDB

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

http://www.wikidata.org/entity/Q30483457

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Modulation of the maladaptive stress response to manage diseases of protein folding Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation Identification of bilateral changes in TID1 expression in the 6-OHDA rat model of Parkinson's disease HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock Heat shock proteins: cellular and molecular mechanisms in the central nervous system.Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease Context dependent neuroprotective properties of prion protein (PrP).Daily timed sexual interaction induces moderate anticipatory activity in mice.Reduction of PrP(C) in human cerebrospinal fluid after spinal cord injury.Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT.Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation.Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.Prion protein biosynthesis and its emerging role in neurodegeneration.Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation.Striatal pathology underlies prion infection-mediated hyperactivity in mice.The unpredictability of prolonged activation of stress response pathways.Heat shock transcription factor 1 is activated as a consequence of lymphocyte activation and regulates a major proteostasis network in T cells critical for cell division during stress Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors.Proteotoxic stress of cancer: implication of the heat-shock response in oncogenesis.Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis Determinants of rodent longevity in the chaperone-protein degradation network.Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.Molecular pathology of human prion diseases.Emergence and natural selection of drug-resistant prions.The heat shock factor family and adaptation to proteotoxic stress.Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity Exploring prion protein biology in flies: genetics and beyond.Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.Transcription factor cooperativity with heat shock factor 1.The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.Shock and awe: unleashing the heat shock response to treat Huntington disease.Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.

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P2860

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

http://www.wikidata.org/entity/Q30483457

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

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PNAS.0806319105

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Proceedings of the National Academy of Sciences of the United States of America

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Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.

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Andrew D Steele

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Andrew W Borkowski

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Frank L Heppner

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Gregory J Raymond

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Oliver D King

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P2860

Molecular chaperones as HSF1-specific transcriptional repressors

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

Signal integration in the endoplasmic reticulum unfolded protein response

Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1

Adapting proteostasis for disease intervention

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes

HSF4 is required for normal cell growth and differentiation during mouse lens development

Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility

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10.1073/PNAS.0806319105

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36

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105

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Susan Lindquist

Walker S Jackson

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2008-08-29T00:00:00Z

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23224089

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18757733

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Prion protein family

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2533240

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