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Oncogenic ras and p53 cooperate to induce cellular senescence

Oncogenic ras and p53 cooperate to induce cellular senescence

http://www.wikidata.org/entity/Q34279104

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CSIG inhibits PTEN translation in replicative senescence DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways Disruptive chemicals, senescence and immortality The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness p19ras brings a new twist to the regulation of p73 by Mdm2 Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer Characterization of the p53 response to oncogene-induced senescence.The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.Likelihood-Based Approach to Gene Set Enrichment Analysis with a Finite Mixture Model Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.Tumor suppression by p53: making cells senescent.p35 is required for CDK5 activation in cellular senescence.Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.Potential malignant transformation in the gastric mucosa of immunodeficient mice with persistent Mycoplasma penetrans infection.Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells.Cellular senescence and protein degradation: breaking down cancer ARF-induced downregulation of Mip130/LIN-9 protein levels mediates a positive feedback that leads to increased expression of p16Ink4a and p19Arf.Paradoxical suppression of cellular senescence by p53 Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation TAp63 induces senescence and suppresses tumorigenesis in vivo.Promotion of direct reprogramming by transformation-deficient Myc.The PML domain of PML-RARα blocks senescence to promote leukemia Bmi1 is down-regulated in the aging brain and displays antioxidant and protective activities in neurons The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence.

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P2860

Oncogenic ras and p53 cooperate to induce cellular senescence

http://www.wikidata.org/entity/Q34279104

description

2002 nî lūn-bûn

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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2002 թվականի մայիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Oncogenic ras and p53 cooperate to induce cellular senescence

@ast

Oncogenic ras and p53 cooperate to induce cellular senescence

@en

Oncogenic ras and p53 cooperate to induce cellular senescence

@nl

type

label

Oncogenic ras and p53 cooperate to induce cellular senescence

@ast

Oncogenic ras and p53 cooperate to induce cellular senescence

@en

Oncogenic ras and p53 cooperate to induce cellular senescence

@nl

prefLabel

Oncogenic ras and p53 cooperate to induce cellular senescence

@ast

Oncogenic ras and p53 cooperate to induce cellular senescence

@en

Oncogenic ras and p53 cooperate to induce cellular senescence

@nl

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MCB.22.10.3497-3508.2002

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Molecular and Cellular Biology

P1476

Oncogenic ras and p53 cooperate to induce cellular senescence

@en

P2093

Athena W Lin

http://www.w3.org/2001/XMLSchema#string

Emmanuelle Querido

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Gerardo Ferbeyre

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Mila E McCurrach

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Scott W Lowe

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P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

Regulation of p53 activity in nuclear bodies by a specific PML isoform

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

SUMO-1 modification activates the transcriptional response of p53

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells

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10.1128/MCB.22.10.3497-3508.2002

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10

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Elisa de Stanchina

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11971980

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133786

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