The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence
about
Raf family kinases: old dogs have learned new tricksVRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signalingSuppression of replicative senescence by rapamycin in rodent embryonic cellsαB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation.Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformationRegulation of glucose homeostasis by KSR1 and MARK2.Scaffold proteins confer diverse regulatory properties to protein kinase cascades.Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis.KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis.Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.Key role of ERK1/2 molecular scaffolds in heart pathology.KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors.KSR as a therapeutic target for Ras-dependent cancers.Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPKKSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputsRas subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteinsCoordinating ERK signaling via the molecular scaffold Kinase Suppressor of RasDifferential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiationKSR1 is required for cell cycle reinitiation following DNA damage.Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.
P2860
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P2860
The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence
description
2006 nî lūn-bûn
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2006 թուականի Մարտին հրատարակուած գիտական յօդուած
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2006 թվականի մարտին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
@zh-hk
2006年論文
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2006年論文
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2006年论文
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name
The molecular scaffold kinase ...... ced and replicative senescence
@ast
The molecular scaffold kinase ...... ced and replicative senescence
@en
The molecular scaffold kinase ...... ced and replicative senescence
@nl
type
label
The molecular scaffold kinase ...... ced and replicative senescence
@ast
The molecular scaffold kinase ...... ced and replicative senescence
@en
The molecular scaffold kinase ...... ced and replicative senescence
@nl
prefLabel
The molecular scaffold kinase ...... ced and replicative senescence
@ast
The molecular scaffold kinase ...... ced and replicative senescence
@en
The molecular scaffold kinase ...... ced and replicative senescence
@nl
P2093
P2860
P1476
The molecular scaffold kinase ...... ced and replicative senescence
@en
P2093
Andrey S Shaw
Angela M Fusello
Deanna J Volle
Diane L Costanzo
Gina L Razidlo
Heidi J Johnson
Robert E Lewis
Robert L Kortum
P2860
P304
P356
10.1128/MCB.26.6.2202-2214.2006
P407
P577
2006-03-01T00:00:00Z