The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence - Wikidata - wikimedia - TriplyDB

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence

http://www.wikidata.org/entity/Q34519801

about

Raf family kinases: old dogs have learned new tricks VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling Suppression of replicative senescence by rapamycin in rodent embryonic cells αB-crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation.Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation Regulation of glucose homeostasis by KSR1 and MARK2.Scaffold proteins confer diverse regulatory properties to protein kinase cascades.Suppression of Ras/Mapk pathway signaling inhibits Myc-induced lymphomagenesis.KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.Monomeric and dimeric models of ERK2 in conjunction with studies on cellular localization, nuclear translocation, and in vitro analysis.Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.Mitogen-Activated Protein (MAP) Kinase Scaffolding Proteins: A Recount.Key role of ERK1/2 molecular scaffolds in heart pathology.KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors.KSR as a therapeutic target for Ras-dependent cancers.Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation KSR1 is required for cell cycle reinitiation following DNA damage.Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP.Homozygous KSR1 deletion attenuates morbidity but does not prevent tumor development in a mouse model of RAS-driven pancreatic cancer.

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The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence

http://www.wikidata.org/entity/Q34519801

description

2006 nî lūn-bûn

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2006 թուականի Մարտին հրատարակուած գիտական յօդուած

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2006 թվականի մարտին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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The molecular scaffold kinase ...... ced and replicative senescence

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MCB.26.6.2202-2214.2006

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Molecular and Cellular Biology

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The molecular scaffold kinase ...... ced and replicative senescence

@en

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Andrey S Shaw

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Angela M Fusello

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Deanna J Volle

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Diane L Costanzo

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Gina L Razidlo

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Heidi J Johnson

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Robert E Lewis

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Robert L Kortum

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P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

WAF1, a potential mediator of p53 tumor suppression

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

PML is a direct p53 target that modulates p53 effector functions

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

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2202-2214

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scholarly article

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10.1128/MCB.26.6.2202-2214.2006

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6

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26

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2006-03-01T00:00:00Z

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16507997

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1430273

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