Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
about
Pyruvate Kinase M2: A Potential Target for Regulating InflammationPyruvate kinase: Function, regulation and role in cancerPyruvate kinase M2 at a glanceAssociations among Metabolism, Circadian Rhythm and Age-Associated DiseasesPKM2: the thread linking energy metabolism reprogramming with epigenetics in cancerEmerging roles of post-translational modifications in signal transduction and angiogenesisActivators of PKM2 in cancer metabolism.Structural insight into mechanisms for dynamic regulation of PKM2.Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue.Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2.Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella VirulenceExpression of pyruvate kinase M2 in human colorectal cancer and its prognostic valueBoth HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells.SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.PKM2 and cancer: The function of PKM2 beyond glycolysis.The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease.Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway.PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation.SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor GrowthEGFR Signaling Regulates Maspin/SerpinB5 Phosphorylation and Nuclear Localization in Mammary Epithelial Cells.Acetylation of Mitochondrial Trifunctional Protein α-Subunit Enhances Its Stability To Promote Fatty Acid Oxidation and Is Decreased in Nonalcoholic Fatty Liver Disease.Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2.Transcription factors, transcriptional coregulators, and epigenetic modulation in the control of pulmonary vascular cell phenotype: therapeutic implications for pulmonary hypertension (2015 Grover Conference series).Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage.Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2.Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth.Dysregulated glycolysis as an oncogenic event.Metabolic control of signalling pathways and metabolic auto-regulation.Targeting cancer cell metabolism in pancreatic adenocarcinoma.Electrophilic Modification of PKM2 by 4-Hydroxynonenal and 4-Oxononenal Results in Protein Cross-Linking and Kinase Inhibition.Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.Parkin Regulates the Activity of Pyruvate Kinase M2Impact of acetylation on tumor metabolism.Metabolic control of epigenetics in cancer.Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation.Expression patterns of three regulation enzymes in glycolysis in esophageal squamous cell carcinoma: association with survival.Changes in PKM2 associate with prostate cancer progression.Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex
P2860
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P2860
Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@ast
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@en
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@nl
type
label
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@ast
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@en
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@nl
prefLabel
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@ast
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@en
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@nl
P2093
P2860
P1433
P1476
Mitogenic and oncogenic stimul ...... vity and nuclear localization.
@en
P2093
Fu-Long Li
Kun-Liang Guan
Naoya Sasaki
Ting-Ting Li
Yan-Ping Xu
Ying Jiang
P2860
P304
P356
10.1016/J.MOLCEL.2013.09.004
P50
P577
2013-10-10T00:00:00Z