LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis - Wikidata - wikimedia - TriplyDB

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

http://www.wikidata.org/entity/Q34282335

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The pathogenesis of chronic lymphocytic leukemia Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease High throughput chemical library screening identifies a novel p110-δ inhibitor that potentiates the anti-myeloma effect of bortezomib Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression.Network Biomarkers Constructed from Gene Expression and Protein-Protein Interaction Data for Accurate Prediction of Leukemia Metadherin contribute to BCR signaling in chronic lymphocytic leukemia Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL.SF3B1 and other novel cancer genes in chronic lymphocytic leukemia PKC-β as a therapeutic target in CLL: PKC inhibitor AEB071 demonstrates preclinical activity in CLL.Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia.Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14.Role of microRNA profile modifications in hepatitis C virus-related mixed cryoglobulinemia Expression and role of RIP140/NRIP1 in chronic lymphocytic leukemia.Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.Characterization of LEF1 High Expression and Novel Mutations in Adult Acute Lymphoblastic Leukemia Methylprednisolone suppresses the Wnt signaling pathway in chronic lymphocytic leukemia cell line MEC-1 regulated by LEF-1 expression Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia.Understanding multicellular function and disease with human tissue-specific networks.Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid Non-myogenic tumors display altered expression of dystrophin (DMD) and a high frequency of genetic alterations.Lymphoid enhancer binding factor-1 (LEF1) expression as a prognostic factor in adult acute promyelocytic leukemia.B-lineage transcription factors and cooperating gene lesions required for leukemia development.Uncovering the DNA methylome in chronic lymphocytic leukemia.Wnt signaling in leukemias and myeloma: T-cell factors are in control.Chronic lymphocytic leukaemia: could immunological tolerance mechanisms be the origin of lymphoid neoplasms?Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells.C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages.Targeting the canonical Wnt/β-catenin pathway in hematological malignancies.GSK3β inactivation induces apoptosis of leukemia cells by repressing the function of c-Myb.Indolent lymphomas in the pediatric population: follicular lymphoma, IRF4/MUM1+ lymphoma, nodal marginal zone lymphoma and chronic lymphocytic leukemia.Blockage of Wnt/β-Catenin Signaling by Nanoparticles Reduces Survival and Proliferation of CLL Cells In Vitro-Preliminary Study.Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.Microenvironmental interactions between endothelial and lymphoma cells: a role for the canonical WNT pathway in Hodgkin lymphoma.A seven-gene expression panel distinguishing clonal expansions of pre-leukemic and chronic lymphocytic leukemia B cells from normal B lymphocytes.Metadherin contributes to the pathogenesis of chronic lymphocytic leukemia partially through Wnt/β-catenin pathway.Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas.

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LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

http://www.wikidata.org/entity/Q34282335

description

2010 nî lūn-bûn

@nan

2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

@ast

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

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LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

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type

label

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

@ast

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

@en

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

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prefLabel

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

@ast

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

@en

LEF-1 is a prosurvival factor ...... onoclonal B-cell lymphocytosis

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Albert Gutierrez

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Diane F Jelinek

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Jeanette Eckel-Passow

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Neil E Kay

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Paul M Huddleston

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Renee C Tschumper

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Susan L Slager

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Tait D Shanafelt

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Xiaosheng Wu

http://www.w3.org/2001/XMLSchema#string

P2860

LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

Identification of c-MYC as a target of the APC pathway

The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.

Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

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2975-2983

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