Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
about
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice.The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytesαβ versus γδ fate choice: counting the T-cell lineages at the branch point.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire.γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation.Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival.ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.Signals and pathways controlling regulatory T cells.The checkpoint for agonist selection precedes conventional selection in human thymus.The transcriptional landscape of αβ T cell differentiation.Involvement of commensal bacteria may lead to dysregulated inflammatory and autoimmune responses in a mouse model for chronic nonsuppurative destructive cholangitis.T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways.
P2860
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P2860
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
description
2005 nî lūn-bûn
@nan
2005 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@ast
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@en
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@nl
type
label
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@ast
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@en
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@nl
prefLabel
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@ast
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@en
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@nl
P2093
P2860
P1476
Regulated costimulation in the ...... bypass the pre-TCR checkpoint
@en
P2093
Baishakhi Choudhury
David Klug
Joy A Williams
Karen S Hathcock
Yohsuke Harada
P2860
P304
P356
10.4049/JIMMUNOL.175.7.4199
P407
P577
2005-10-01T00:00:00Z