A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.
about
Drugging topoisomerases: lessons and challengesTopoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sitesComparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification.Single-Molecule Supercoil Relaxation Assay as a Screening Tool to Determine the Mechanism and Efficacy of Human Topoisomerase IB Inhibitors.Mitochondrial protein-linked DNA breaks perturb mitochondrial gene transcription and trigger free radical-induced DNA damage.The dynamic interplay between DNA topoisomerases and DNA topology.Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Poisoning of mitochondrial topoisomerase I by lamellarin DMapping topoisomerase sites in mitochondrial DNA with a poisonous mitochondrial topoisomerase I (Top1mt).Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V.RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.Torsionally constrained DNA for single-molecule assays: an efficient, ligation-free methodSynthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776).Gold(III) macrocycles: nucleotide-specific unconventional catalytic inhibitors of human topoisomerase I.F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.Distribution bias and biochemical characterization of TOP1MT single nucleotide variants.A highly processive topoisomerase I: studies at the single-molecule level.Single molecule measurements of DNA helicase activity with magnetic tweezers and t-test based step-finding analysis.Variola type IB DNA topoisomerase: DNA binding and supercoil unwinding using engineered DNA minicircles.Simulation of DNA Supercoil RelaxationThe Dynamic Interplay Between DNA Topoisomerases and DNA Topology.Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy.
P2860
Q27000099-F10DC55F-ED6D-4802-B63D-EF141D58F1B3Q28260713-C27FF51F-04CA-4360-9CD2-4657CFCCD09CQ30539075-098C8AFB-BA29-49AC-98DB-6707144E2513Q30673594-3C6CAC53-7944-4BFD-AA9F-0925332ED7A2Q33615689-7E5D8378-70A3-4793-900F-35EF6D739863Q33639806-4DE6E5EB-D421-48D6-BFB3-59EFCF73A899Q33791241-BB2C1BE1-53B5-4476-A0B1-AF20FEC0602EQ33875792-D591E823-5D2F-4F31-B28C-5AD619A3FD36Q34024641-7A2C0F67-57F4-491A-BE10-073FB0E5F5F3Q34073898-C9544C7D-4645-47B0-AB32-0399C7CC975AQ34355616-516086EF-30B1-4DB9-9C0E-13BBA99A14E2Q37197457-63C74D88-C335-4480-B138-CC898ABABB28Q37236787-4E179D99-8B14-484F-A409-18A431B95794Q37697354-E1F1AF78-CCEE-479E-BF45-BBBDCC37DC11Q37731572-34AB4AC7-B874-430A-A2E3-10C79883DB52Q38849714-F506CB52-01B6-46C5-9166-D81572F5E1D0Q41447217-D51D26B7-02D6-4F44-8BEE-BA62C94046ADQ42072091-DFC46893-6A4B-4ACE-9B09-B759DF3CE430Q42103628-0847947A-0B6E-4BC3-9AE2-2B050F6D970CQ42211325-C6170B63-13E8-44E2-A3D5-434D201A33FCQ42570298-259CB347-0D61-45AD-A515-0F9126C37CC4Q51273340-B9238C5A-FD69-4BD0-BDC2-E23BCF0ADF35Q55512580-D032D0B3-01B7-4291-AFCF-E9D296A8BEA1
P2860
A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity.
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@ast
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@en
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@nl
type
label
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@ast
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@en
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@nl
prefLabel
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@ast
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@en
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@nl
P2093
P2860
P356
P1476
A kinetic clutch governs relig ...... ines camptothecin sensitivity.
@en
P2093
Hongliang Zhang
Keir C Neuman
Yeonee Seol
P2860
P304
16125-16130
P356
10.1073/PNAS.1206480109
P407
P50
P577
2012-09-18T00:00:00Z