Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
about
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channelsBK channels: multiple sensors, one activation gateTwo separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channelsIdentification and analysis of cation channel homologues in human pathogenic fungiFluorescence applications in molecular neurobiologyDesign and characterization of a constitutively open KcsA.Models of the structure and voltage-gating mechanism of the shaker K+ channel.Generation, comparison, and merging of pathways between protein conformations: gating in K-channels.Monte Carlo-energy minimization of correolide in the Kv1.3 channel: possible role of potassium ion in ligand-receptor interactions.Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation.Multi-scale electrophysiology modeling: from atom to organStructure-functional intimacies of transient receptor potential channels.Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactionsIon channel voltage sensors: structure, function, and pathophysiology.Coupled motions between pore and voltage-sensor domains: a model for Shaker B, a voltage-gated potassium channelDefining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites.Rapid intracellular TEA block of the KcsA potassium channel.The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers.Ion channel associated diseases: overview of molecular mechanismsKvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experimentsPosition and motions of the S4 helix during opening of the Shaker potassium channel.State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.The cooperative voltage sensor motion that gates a potassium channel.Environment of the gating charges in the Kv1.2 Shaker potassium channelRole of conserved glycines in pH gating of Kir1.1 (ROMK)Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain.Common mechanism of pore opening shared by five different potassium channelsElucidating the molecular basis of action of a classic drug: guanidine compounds as inhibitors of voltage-gated potassium channels.Molecular restraints in the permeation pathway of ion channels.Cysteine scanning and modification reveal major differences between BK channels and Kv channels in the inner pore region.Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelMutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91.Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implicationsDisulfide trapping the mechanosensitive channel MscL into a gating-transition state.Status of the intracellular gate in the activated-not-open state of shaker K+ channelsTwo atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel.Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.
P2860
Q26800090-C1FF2CE8-E898-4731-9C43-66C18CAE178EQ26830341-89700E0B-D90E-4D24-BA41-AC8B7EF730B1Q28474961-9CDFFE67-5788-4280-952A-3FE15CCED678Q28481844-21F608BD-C156-4746-82CE-C6D5F07362B0Q30388741-A8D6F009-0BF9-4C9C-BE2B-7BAF3E9B5183Q30432912-04D78CC7-37FE-4158-BCB9-6F29DAAA77EDQ30476448-9BB9C442-BEBE-4FAD-A460-351E2B290DDFQ30483732-38F00CA0-2791-414B-97EA-F06C89953039Q33270767-B71B167C-B8AD-4EA8-A489-CBB2F0D21F63Q33582414-85913B32-8EF2-4F88-ADD2-917D0CFC9EADQ33725846-DB0BF060-FF6F-4654-9FBA-A95547AB85C3Q33754946-045EE5BC-E953-4723-884D-2D017843BBDDQ33775096-7996D309-5BED-45B1-8E43-CD1A5A362F9AQ33922826-24F3F386-E9F1-42B7-899F-0EE48C514C66Q34089246-C2109A64-D049-4507-BD4C-D0C2F8D5A457Q34107486-CB7BE354-CB5C-4E9C-AB74-61F8FB7A712AQ34139997-4F54D0E9-221C-41B2-983B-7BC66A1489E8Q34187314-B0E9BF98-AC27-4C03-A4CA-12D8DC6E5DFCQ34187668-A3350F46-54BE-4917-B26B-C89CC6FBE992Q34188864-66855BCF-0056-4A35-94A2-D89A51966239Q34243021-84DA81E7-6D9F-44AF-A1D0-E1F5157FA5ECQ34311621-D73CB246-E1F5-4A79-890F-CA379E5FDAA8Q34350671-EC18B0BB-DF4E-426B-A709-4604AE4AA7ACQ34368444-D38A3D76-7A6A-4CD3-A2F7-049CD762D64DQ34412519-B51E0649-A5DE-45A3-AE63-95DEF0E4040EQ34482244-19EAD7F1-C1A1-4E70-9F88-EC6395A3A604Q34524677-70BB4455-0DEE-463F-BE64-6680F2F3E5B5Q34546935-EA36B4B1-B75E-441C-8725-9B9E9DFA67F8Q34566675-AF5E939E-0506-49A8-8C9C-5C68881653CDQ34600882-12D7A4A3-5C68-4E79-A00F-7A6E1C7D1978Q34632406-BFB66E1D-B889-40B4-90AC-7410203EA0F6Q35023843-979E00AA-ED68-4430-AE0A-75316E3FAA9BQ35123192-B036FD7D-1F58-442C-B834-0D8879903F02Q35240329-43658269-FE9A-4068-BAAE-A29B23DCC527Q35470532-E9956AB5-8EFD-4029-BACC-5A18AD7D6A1DQ35549225-32B9B4D1-D9C3-4661-84AA-B9711258284EQ35613680-71DCF6A4-3142-4DC5-9319-5CF080CBB0FAQ35629078-FC1D994D-E219-40B7-AF03-45C7AE144C47Q35808791-54A938D7-5BC4-4E53-9BC6-99542E67339DQ35963083-1463AFC9-5D8F-4E86-8E22-FD4B9578B626
P2860
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@ast
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@en
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@nl
type
label
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@ast
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@en
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@nl
prefLabel
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@ast
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@en
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
@nl
P2860
P356
P1433
P1476
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
@en
P2093
Donato Del Camino
John P Dekker
P2860
P2888
P304
P356
10.1038/NATURE02468
P407
P577
2004-04-01T00:00:00Z
P5875
P6179
1034987114