about
Specific in vivo knockdown of protein function by intrabodiesTargeting SH2 domains in breast cancerCrystal structure of human protein-tyrosine phosphatase SHP-1Structural and energetic aspects of Grb2-SH2 domain-swappingA potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainThe paradox of conformational constraint in the design of Cbl(TKB)-binding peptidesIdentification of Shc Src homology 2 domain-binding peptoid-peptide hybridsA phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.Progress towards the development of SH2 domain inhibitors.Ras-MAP kinase signaling pathways and control of cell proliferation: relevance to cancer therapy.Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection.High affinity molecules disrupting GRB2 protein complexes as a therapeutic strategy for chronic myelogenous leukaemia.Peptides with anticancer use or potential.Exploiting the P-1 pocket of BRCT domains toward a structure guided inhibitor design.Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold.Phosphoinositide, phosphopeptide and pyridone interactions of the Abl SH2 domainProtein-protein interactions as targets for small-molecule therapeutics in cancer.Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.SHIP2: Structure, Function and Inhibition.Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs.Quantum mechanical binding free energy calculation for phosphopeptide inhibitors of the Lck SH2 domain.Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry.Current chemical biology tools for studying protein phosphorylation and dephosphorylation.Specific peptide ligand for Grb7 signal transduction protein and pancreatic cancer metastasis.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
SH2 domain inhibition: a problem solved?
@ast
SH2 domain inhibition: a problem solved?
@en
SH2 domain inhibition: a problem solved?
@nl
type
label
SH2 domain inhibition: a problem solved?
@ast
SH2 domain inhibition: a problem solved?
@en
SH2 domain inhibition: a problem solved?
@nl
prefLabel
SH2 domain inhibition: a problem solved?
@ast
SH2 domain inhibition: a problem solved?
@en
SH2 domain inhibition: a problem solved?
@nl
P1476
SH2 domain inhibition: a problem solved?
@en
P2093
Shakespeare WC
P304
P356
10.1016/S1367-5931(00)00222-2
P577
2001-08-01T00:00:00Z