Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.
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Improved targeting of miRNA with antisense oligonucleotidesCrystallographic studies of chemically modified nucleic acids: a backward glanceChimeric RNase H-competent oligonucleotides directed to the HIV-1 Rev response elementEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainStabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidinesInsights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complexA conformational transition in the structure of a 2′-thiomethyl-modified DNA visualized at high resolutionRibonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotidesHuman RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processingOligonucleotide-based strategies to combat polyglutamine diseases.RNase H-mediated degradation of toxic RNA in myotonic dystrophy type 1Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.Crystallization and preliminary X-ray analysis of Escherichia coli RNase HI-dsRNA complexes.Cloning, expression, purification and preliminary crystallographic analysis of the RNase HI domain of the Mycobacterium tuberculosis protein Rv2228c as a maltose-binding protein fusion.Antisense oligonucleotides: rising stars in eliminating RNA toxicity in myotonic dystrophy.2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase HRational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS.New Modalities for Challenging Targets in Drug Discovery.4'-Epi-DNA: A DNA Mimic Containing 4'-hydroxymethyl-α-l-Xylo-Thymidine with Compact Backbone like RNA.Investigating HIV-1 polypurine tract geometry via targeted insertion of abasic lesions in the (-)-DNA template and (+)-RNA primer.Oligonucleotide therapeutics: chemistry, delivery and clinical progress.Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides.5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes.mRNA knockdown by single strand RNA is improved by chemical modificationsMolecular Mechanisms of Antisense Oligonucleotides.Binding and cleavage specificities of human Argonaute2.Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals.2'-SCF3 uridine-a powerful label for probing structure and function of RNA by 19F NMR spectroscopy.RNA-directed off/on switch of RNase H activity using boronic ester formation.How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells.
P2860
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P2860
Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Structural requirements at the ...... for human RNase H1 catalysis.
@ast
Structural requirements at the ...... for human RNase H1 catalysis.
@en
Structural requirements at the ...... for human RNase H1 catalysis.
@nl
type
label
Structural requirements at the ...... for human RNase H1 catalysis.
@ast
Structural requirements at the ...... for human RNase H1 catalysis.
@en
Structural requirements at the ...... for human RNase H1 catalysis.
@nl
prefLabel
Structural requirements at the ...... for human RNase H1 catalysis.
@ast
Structural requirements at the ...... for human RNase H1 catalysis.
@en
Structural requirements at the ...... for human RNase H1 catalysis.
@nl
P2093
P2860
P356
P1476
Structural requirements at the ...... for human RNase H1 catalysis.
@en
P2093
Balkrishen Bhat
Hongjiang Wu
Josh G Nichols
Mike T Migawa
Stanley T Crooke
Tadensz K Wyrzykiewicz
Thazha P Prakash
Walt F Lima
P2860
P304
36317-36326
P356
10.1074/JBC.M405035200
P407
P577
2004-06-17T00:00:00Z