Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
about
Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranesPrenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cellsInfluence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-IPrenylation of Rab8 GTPase by type I and type II geranylgeranyl transferasesRab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5APurification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteinsStructures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylationThe putative "switch 2" domain of the Ras-related GTPase, Rab1B, plays an essential role in the interaction with Rab escort proteinRapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.A comprehensive review of retinal gene therapyGDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway.Identification of yeast component A: reconstitution of the geranylgeranyltransferase that modifies Ypt1p and Sec4p.Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamilyYop1p, the yeast homolog of the polyposis locus protein 1, interacts with Yip1p and negatively regulates cell growth.Isoprenylation of Rab proteins possessing a C-terminal CaaX motifProtein prenyltransferasesCAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoBRab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesisRab27a regulates the peripheral distribution of melanosomes in melanocytesA Comprehensive Analysis of Choroideremia: From Genetic Characterization to Clinical PracticeMutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells.High-resolution images of retinal structure in patients with choroideremia.Recent advances in the gene map of inherited eye disorders: primary hereditary diseases of the retina, choroid, and vitreous.Expression and localization of rab escort protein isoforms in parotid acinar cells from rat.Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.Scientific side trips: six excursions from the beaten path.Deficient geranylgeranylation of Ram/Rab27 in choroideremia.Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease.Characterization of the interaction of the monomeric GTP-binding protein Rab3a with geranylgeranyl transferase II.Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.A single residue can modify target-binding affinity and activity of the functional domain of the Rho-subfamily GDP dissociation inhibitors.AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models.Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremiaGene therapy for choroideremia using an adeno-associated viral (AAV) vector.Proof of concept for AAV2/5-mediated gene therapy in iPSC-derived retinal pigment epithelium of a choroideremia patient.Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycleProtein prenylation in spinach chloroplasts.Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia.MERTK signaling in the retinal pigment epithelium regulates the tyrosine phosphorylation of GDP dissociation inhibitor alpha from the GDI/CHM family of RAB GTPase effectors.Pathogenic mechanisms and the prospect of gene therapy for choroideremia.
P2860
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P2860
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Purification of component A of ...... he choroideremia gene product.
@ast
Purification of component A of ...... he choroideremia gene product.
@en
Purification of component A of ...... he choroideremia gene product.
@nl
type
label
Purification of component A of ...... he choroideremia gene product.
@ast
Purification of component A of ...... he choroideremia gene product.
@en
Purification of component A of ...... he choroideremia gene product.
@nl
prefLabel
Purification of component A of ...... he choroideremia gene product.
@ast
Purification of component A of ...... he choroideremia gene product.
@en
Purification of component A of ...... he choroideremia gene product.
@nl
P2093
P1433
P1476
Purification of component A of ...... he choroideremia gene product.
@en
P2093
C A Slaughter
J L Goldstein
M C Seabra
P304
P356
10.1016/0092-8674(92)90253-9
P407
P577
1992-09-01T00:00:00Z