Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. - Wikidata - wikimedia - TriplyDB

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.

http://www.wikidata.org/entity/Q34335155

about

Down syndrome: searching for the genetic culprits Prospects for Improving Brain Function in Individuals with Down Syndrome Emerging pharmacotherapies for neurodevelopmental disorders Timing of therapies for Down syndrome: the sooner, the better Building an adaptive brain across development: targets for neurorehabilitation must begin in infancy Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations.The use of mouse models to understand and improve cognitive deficits in Down syndrome.Brain plasticity and disease: a matter of inhibition.Lithium rescues synaptic plasticity and memory in Down syndrome mice.A very rare cancer in Down syndrome: medulloblastoma. Epidemiological data from 13 countries.Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Understanding the basis for Down syndrome phenotypes.An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model.Gene expression signature of cerebellar hypoplasia in a mouse model of Down syndrome during postnatal development.Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model Molecular basis of pharmacotherapies for cognition in Down syndrome Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome.A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome.Commonality in Down and fetal alcohol syndromes.Abnormal microRNA expression in Ts65Dn hippocampus and whole blood: contributions to Down syndrome phenotypes.Genome-wide expression analysis in Down syndrome: insight into immunodeficiency.Development and validation of the Arizona Cognitive Test Battery for Down syndrome.Down syndrome--recent progress and future prospects.Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice.Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology.A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Trisomy 21 and early brain development Gene expression variation in Down's syndrome mice allows prioritization of candidate genes Natural gene-expression variation in Down syndrome modulates the outcome of gene-dosage imbalance Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1 The power of comparative and developmental studies for mouse models of Down syndrome Increased excitability and altered action potential waveform in cerebellar granule neurons of the Ts65Dn mouse model of Down syndrome Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome.Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice.The cognitive phenotype of Down syndrome: insights from intracellular network analysis Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration.

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P2860

Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice.

http://www.wikidata.org/entity/Q34335155

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Defective cerebellar response ...... own [corrected] syndrome mice.

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Defective cerebellar response ...... own [corrected] syndrome mice.

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Defective cerebellar response ...... own [corrected] syndrome mice.

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Donna K Klinedinst

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Nidhi G Saran

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Philip A Beachy

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P2860

Small molecule modulation of Smoothened activity

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

Chromosome 21 and down syndrome: from genomics to pathophysiology

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

Sonic hedgehog regulates the growth and patterning of the cerebellum

Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog

Altered neural cell fates and medulloblastoma in mouse patched mutants

Directed differentiation of embryonic stem cells into motor neurons

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