Comprehensive peptidomimetic libraries targeting protein-protein interactions.
about
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactionsβ-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase.Discovery libraries targeting the major enzyme classes: the serine hydrolases.Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domainRole of the axonal initial segment in psychiatric disorders: function, dysfunction, and interventionTargeting protein-protein interactions as an anticancer strategyOvercoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.Balancing novelty with confined chemical space in modern drug discovery.Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative.State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Inhibitors of Ras-SOS Interactions.Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists.DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP PeptidaseRecapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein-protein interactions.Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.Mimicking nature with synthetic macromolecules capable of recognition.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Towards the Next Generation of Computational Chemogenomics Tools.Characterizing the Hot Spots Involved in RON-MSPβ Complex Formation Using In Silico Alanine Scanning Mutagenesis and Molecular Dynamics Simulation.Efficient α-helix induction in a linear peptide chain by N-capping with a bridged-tricyclic diproline analogue.From Peptides to Peptidomimetics: A Strategy Based on the Structural Features of Cyclopropane.Highly sensitive protein detection based on a novel probe with catalytic activity combined with a signal amplification strategy: assay of MDM2 for cancer staging.A modular synthesis of teraryl-based α-helix mimetics, part 1: Synthesis of core fragments with two electronically differentiated leaving groups.De Novo Design and Synthesis of a γ-Turn Peptidomimetic Scaffold and Its Application as JNK3 Allosteric Ligand.Peptidines: glycine-amidine-based oligomers for solution- and solid-phase synthesis† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data of new compounds. CCDC 1430515. For ESI and crystallographic dSynthesis and analysis of the conformational preferences of 5-aminomethyloxazolidine-2,4-dione scaffolds: first examples of β(2)- and β(2, 2)-homo-Freidinger lactam analogues
P2860
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P2860
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@ast
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@en
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@nl
type
label
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@ast
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@en
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@nl
prefLabel
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@ast
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@en
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@nl
P2860
P356
P1476
Comprehensive peptidomimetic libraries targeting protein-protein interactions.
@en
P2093
Dale L Boger
Landon R Whitby
P2860
P304
P356
10.1021/AR300025N
P407
P577
2012-07-16T00:00:00Z