Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid - Wikidata - wikimedia - TriplyDB

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

http://www.wikidata.org/entity/Q34339243

about

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides Vaccine adjuvants as potential cancer immunotherapeutics The Next Hurdle in Cancer Immunotherapy: Overcoming the Non-T-Cell-Inflamed Tumor Microenvironment DNA vaccines: a simple DNA sensing matter?The STING pathway and the T cell-inflamed tumor microenvironment Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer Interferons and viruses: an evolutionary arms race of molecular interactions Rat and human STINGs profile similarly towards anticancer/antiviral compounds New perspectives on type I IFNs in cancer Proteomic response to 5,6-dimethylxanthenone 4-acetic acid (DMXAA, vadimezan) in human non-small cell lung cancer A549 cells determined by the stable-isotope labeling by amino acids in cell culture (SILAC) approach Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses Combining vasculature disrupting agent and Toll-like receptor 7/8 agonist for cancer therapy.Casein kinase II controls TBK1/IRF3 activation in IFN response against viral infection.Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1 Identification of a small molecule that primes the type I interferon response to cytosolic DNA.DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2'3'-cGAMP, induces M2 macrophage repolarization Activation of the STING adaptor attenuates experimental autoimmune encephalitis.The SKIV2L RNA exosome limits activation of the RIG-I-like receptors cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.STING agonists induce an innate antiviral immune response against hepatitis B virus.Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA.The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity.Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response.Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.Cre-dependent DNA recombination activates a STING-dependent innate immune response The host STING pathway at the interface of cancer and immunity Anticancer flavonoids are mouse-selective STING agonists.Molecular mechanism of divalent-metal-induced activation of NS3 helicase and insights into Zika virus inhibitor design.Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways STING, nanoparticles, autoimmune disease and cancer: a novel paradigm for immunotherapy?Microbial DNA recognition by cGAS-STING and other sensors in dendritic cells in inflammatory bowel diseases.

P2860

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P2860

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

http://www.wikidata.org/entity/Q34339243

description

2013 nî lūn-bûn

@nan

2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

@ast

Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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type

label

Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

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JIMMUNOL.1300097

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Journal of Immunology

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Mouse, but not human STING, bi ...... methylxanthenone-4-acetic acid

@en

P2093

Brian Monks

http://www.w3.org/2001/XMLSchema#string

Dara L Burdette

http://www.w3.org/2001/XMLSchema#string

Joseph Conlon

http://www.w3.org/2001/XMLSchema#string

Katherine A Fitzgerald

http://www.w3.org/2001/XMLSchema#string

Mikayla Thompson

http://www.w3.org/2001/XMLSchema#string

Numana Bhat

http://www.w3.org/2001/XMLSchema#string

Russell E Vance

http://www.w3.org/2001/XMLSchema#string

Shruti Sharma

http://www.w3.org/2001/XMLSchema#string

Stefanie N Vogel

http://www.w3.org/2001/XMLSchema#string

T Sam Xiao

http://www.w3.org/2001/XMLSchema#string

P2860

IFI16 is an innate immune sensor for intracellular DNA

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Cyclic di-GMP sensing via the innate immune signaling protein STING

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

STING is a direct innate immune sensor of cyclic di-GMP

P304

5216-5225

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scholarly article

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10.4049/JIMMUNOL.1300097

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10

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190

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23585680

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3647383

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