The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING - Wikidata - wikimedia - TriplyDB

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

http://www.wikidata.org/entity/Q34346633

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Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.Cytosolic Innate Immune Sensing and Signaling upon Infection STING: infection, inflammation and cancer Recognition of cytosolic DNA by cGAS and other STING-dependent sensors Microbial biofilm formation: a need to act The enemy within: endogenous retroelements and autoimmune disease Crosstalk between Mycobacterium tuberculosis and the host cell Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry–related pockets New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16 Evasion of host antiviral innate immunity by HSV-1, an update Old concepts, new molecules and current approaches applied to the bacterial nucleotide signalling field Molecular Pathways: Targeting the Stimulator of Interferon Genes (STING) in the Immunotherapy of Cancer International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease Rat and human STINGs profile similarly towards anticancer/antiviral compounds Role of the HIN domain in regulation of innate immune responses Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses.Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity.Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.Cyclic GMP-AMP displays mucosal adjuvant activity in mice Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP Control of bacterial exoelectrogenesis by c-AMP-GMP.Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP The mechanism of double-stranded DNA sensing through the cGAS-STING pathway

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

http://www.wikidata.org/entity/Q34346633

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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type

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The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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prefLabel

The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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The innate immune DNA sensor c ...... ide that activates human STING

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J.CELREP.2013.05.009

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The innate immune DNA sensor c ...... ide that activates human STING

@en

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Colleen A Kellenberger

http://www.w3.org/2001/XMLSchema#string

Dara L Burdette

http://www.w3.org/2001/XMLSchema#string

Elie J Diner

http://www.w3.org/2001/XMLSchema#string

Kathryn M Monroe

http://www.w3.org/2001/XMLSchema#string

Ming C Hammond

http://www.w3.org/2001/XMLSchema#string

Russell E Vance

http://www.w3.org/2001/XMLSchema#string

Stephen C Wilson

http://www.w3.org/2001/XMLSchema#string

Yoshihiro Hayakawa

http://www.w3.org/2001/XMLSchema#string

P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Cyclic di-GMP sensing via the innate immune signaling protein STING

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

STING is a direct innate immune sensor of cyclic di-GMP

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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1355-1361

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scholarly article

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10.1016/J.CELREP.2013.05.009

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5

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3

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2013-05-23T00:00:00Z

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236938212

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23707065

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3706192

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