Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. - Wikidata - wikimedia - TriplyDB

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.

http://www.wikidata.org/entity/Q34340626

about

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1 Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Molecular programming of B cell memory Regulation of Aicda expression and AID activity Transcriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrity AID/APOBEC deaminases and cancer Functions and regulation of the APOBEC family of proteins Lysine residue at position 22 of the AID protein regulates its class switch activity.Complex regulation and function of activation-induced cytidine deaminase.Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm.Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1α (eEF1A).Splice variants of activation induced deaminase (AID) do not affect the efficiency of class switch recombination in murine CH12F3 cells.Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.AIDing cancer treatment: Reducing AID activity via HSP90 inhibition Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Activation-induced Cytidine Deaminase in B Cell Immunity and Cancers.GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.B cell-specific deficiencies in mTOR limit humoral immune responses.Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket.Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells.Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells.Structural and functional assessment of APOBEC3G macromolecular complexes.Cyclin-dependent kinases regulate Ig class switching by controlling access of AID to the switch region.The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.YY1 controls immunoglobulin class switch recombination and nuclear activation-induced deaminase levels.Heat shock proteins stimulate APOBEC-3-mediated cytidine deamination in the hepatitis B virus.APOBEC3 proteins and genomic stability: the high cost of a good defense Alternative splice variants of AID are not stoichiometrically present at the protein level in chronic lymphocytic leukemia AID Biology: A pathological and clinical perspective.Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination Pharmacological manipulation of AID.

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P2860

Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.

http://www.wikidata.org/entity/Q34340626

description

2010 nî lūn-bûn

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2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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name

Regulation of activation-induc ...... gene diversification by Hsp90.

@ast

Regulation of activation-induc ...... gene diversification by Hsp90.

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Regulation of activation-induc ...... gene diversification by Hsp90.

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type

label

Regulation of activation-induc ...... gene diversification by Hsp90.

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Regulation of activation-induc ...... gene diversification by Hsp90.

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Regulation of activation-induc ...... gene diversification by Hsp90.

@nl

prefLabel

Regulation of activation-induc ...... gene diversification by Hsp90.

@ast

Regulation of activation-induc ...... gene diversification by Hsp90.

@en

Regulation of activation-induc ...... gene diversification by Hsp90.

@nl

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P1433

Journal of Experimental Medicine

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Regulation of activation-induc ...... gene diversification by Hsp90

@en

P2093

Alain Lamarre

http://www.w3.org/2001/XMLSchema#string

Alexandre Orthwein

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Anne-Marie Patenaude

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El Bachir Affar

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Jason C Young

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P2860

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperone

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

Reprogramming towards pluripotency requires AID-dependent DNA demethylation

MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation

MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase

Activation-induced cytidine deaminase initiates immunoglobulin gene conversion and hypermutation by a common intermediate

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2751-2765

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scholarly article

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10.1084/JEM.20101321

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12

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207

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Javier M Di Noia

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2010-11-01T00:00:00Z

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47644739

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21041454

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2989769

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