Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
about
Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KITAn algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluationsSelective inhibition of BET bromodomainsAllosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1Lessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaProfile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemiaOncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formationEffects of STI571 (gleevec) on pancreatic cancer cell growthPharmacology and rationale for imatinib in the treatment of sclerodermaImatinib in chronic myeloid leukemia: an overviewSystems genetics for drug target discoveryLow doses of imatinib induce myelopoiesis and enhance host anti-microbial immunityCrystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding ModesReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timeCurrent management and prognostic features for gastrointestinal stromal tumor (GIST)Random mutagenesis reveals residues of JAK2 critical in evading inhibition by a tyrosine kinase inhibitorNF-kappaB activity is constitutively elevated in c-Abl null fibroblastsA novel quantitative kinase assay using bacterial surface display and flow cytometryGraph theory enables drug repurposing--how a mathematical model can drive the discovery of hidden mechanisms of actionNovel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia CellsA Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizers to Dasatinib Therapy for the Treatment of Epithelial Ovarian CancerNa+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cellsIcaritin shows potent anti-leukemia activity on chronic myeloid leukemia in vitro and in vivo by regulating MAPK/ERK/JNK and JAK2/STAT3 /AKT signalingsSimultaneous visualization of both signaling cascade activity and end-point gene expression in single cellsRegulation of cell migration and survival by focal adhesion targeting of Lasp-1Abelson tyrosine kinase facilitates Salmonella enterica serovar Typhimurium entry into epithelial cells.Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.Development and validation of a sensitive assay for the quantification of imatinib using LC/LC-MS/MS in human whole blood and cell culture.Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia.Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08).Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases.A magnetic bead-based protein kinase assay with dual detection techniques.PDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.STAT signaling in the pathogenesis and treatment of cancerBioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China.Molecular measurement of BCR-ABL transcript variations in chronic myeloid leukemia patients in cytogenetic remission.A PPARγ transcriptional cascade directs adipose progenitor cell-niche interaction and niche expansion.
P2860
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P2860
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
description
1996 nî lūn-bûn
@nan
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@ast
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@en
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@nl
type
label
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@ast
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@en
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@nl
prefLabel
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@ast
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@en
Inhibition of the Abl protein- ...... nylaminopyrimidine derivative.
@nl
P2093
P1433
P1476
Inhibition of the Abl protein- ...... enylaminopyrimidine derivative
@en
P2093
Buchdunger E
Zimmermann J
P304
P407
P577
1996-01-01T00:00:00Z