Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
about
Directed Chemical Evolution with an Outsized Genetic CodeTendons – time to revisit inflammationThe Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded LibraryPrivileged s-triazines: structure and pharmacological applications.Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags.Identification of structure-activity relationships from screening a structurally compact DNA-encoded chemical library.Novel selection methods for DNA-encoded chemical librariesInterrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins.Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2-Aryl Benzimidazole BCATm InhibitorsOptimized Reaction Conditions for Amide Bond Formation in DNA-Encoded Combinatorial LibrariesDNA-encoded chemical libraries: foundations and applications in lead discovery.Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNA-Encoded Chemical Library.The role of aggrecan in normal and osteoarthritic cartilage.Delineating the synovial fluid proteome: recent advancements and ongoing challenges in biomarker research.Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.Design, preparation, and selection of DNA-encoded dynamic librariesPrioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.RIP3 induces apoptosis independent of pronecrotic kinase activity.High-throughput screening and structure-based approaches to hit discovery: is there a clear winner?The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis.
P2860
Q28553436-FDE16D10-13AC-49A0-B435-400331FEB37BQ29398484-649163A2-7ABD-4656-8770-32A49BED7F72Q30375457-B82B8FA2-19A1-4468-9528-59ADAC9A0801Q30378123-810E99AA-C2E8-4DB1-BB48-DBC16E849735Q35122369-7FE67E8A-6A65-4D16-B474-0940DC0DE58DQ35498513-0A1180B2-AE41-403C-8273-E9D9641CA0C4Q35554930-E095F4E6-BA21-4033-8C98-3E31FA5B483EQ35568757-8247519F-61BA-405F-B1EB-779D0894B6DEQ35580534-96AD7787-B61D-46C3-AB1D-E9604D2F4642Q35640508-E81E1140-4B58-490A-84D8-102D2C383C3DQ35659679-173D8B13-6AEE-456A-95B8-6FA2EE198D8DQ35750505-49168805-D79B-422D-94C6-1C88BA96199CQ35893758-ED8D5B64-D540-4A17-9DBD-CEBEDE6B5EBDQ35994507-0B3259F0-9AC6-4BD2-AFD0-E8DF56635488Q36055456-8551EC38-C802-4139-91F9-6C3AFCD2BD95Q36091299-B260B143-38AE-4C60-A431-8D89C4EEBE67Q36198399-441CE384-C427-4523-A064-CFD5D2AA8727Q36240548-AA58C5AA-DC60-45F2-B2C5-82CAE77591DAQ36289587-9C242BDC-959F-4DCC-8D95-2BFD79D96315Q38113846-5F45ECCC-F2D2-455A-9BC6-102C3169CA1EQ38261368-D186ABE3-86BA-4E3D-B34E-EA07C84C0B3FQ38326581-C03D4E5C-4DE6-4811-B683-E4C48ED56FE8Q41011926-3CB9AE5B-2CCE-4350-BA99-38DF763A701BQ41077819-587FC31E-AEF1-4E5D-98F0-93E4801755E5Q42379853-1120E52E-B4C7-41DF-85F6-1F3634FD3F9DQ51344025-62DE1C5A-846E-44D2-A443-1A14D984FFDEQ55025580-9E919120-B5ED-4C11-8AA6-3DE7C0CBB8FB
P2860
Discovery of highly potent and selective small molecule ADAMTS-5 inhibitors that inhibit human cartilage degradation via encoded library technology (ELT).
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Discovery of highly potent and ...... oded library technology (ELT).
@ast
Discovery of highly potent and ...... oded library technology (ELT).
@en
Discovery of highly potent and ...... via encoded library technology
@nl
type
label
Discovery of highly potent and ...... oded library technology (ELT).
@ast
Discovery of highly potent and ...... oded library technology (ELT).
@en
Discovery of highly potent and ...... via encoded library technology
@nl
prefLabel
Discovery of highly potent and ...... oded library technology (ELT).
@ast
Discovery of highly potent and ...... oded library technology (ELT).
@en
Discovery of highly potent and ...... via encoded library technology
@nl
P2093
P356
P1476
Discovery of highly potent and ...... coded library technology (ELT)
@en
P2093
Barry A Morgan
Christopher C Arico-Muendel
Christopher P Davie
G Joseph Franklin
Gary K O'Donovan
Heather O'Keefe
Hongfeng Deng
Jeffrey W Gross
Jonathan Larkin
Katie L Sargent Bedard
P304
P356
10.1021/JM300449X
P407
P577
2012-08-14T00:00:00Z