Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
about
Targeting LKB1 in cancer - exposing and exploiting vulnerabilitiesHyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Müllerian duct mesenchyme-derived myometria.The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.Do hereditary syndrome-related gynecologic cancers have any specific features?Technical challenges and limitations of current mouse models of ovarian cancer.Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in miceGerm cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal developmentProgesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapyHereditary gynecological tumors associated with Peutz-Jeghers syndrome (Review)PI3K/Akt/mTOR signaling & its regulator tumour suppressor genes PTEN & LKB1 in human uterine leiomyomas.Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesionsOveractive mTOR signaling leads to endometrial hyperplasia in aged women and mice.Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.Loss of p27 Associated with Risk for Endometrial Carcinoma Arising in the Setting of Obesity.Loss of LKB1 and p53 synergizes to alter fallopian tube epithelial phenotype and high-grade serous tumorigenesis.Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice.Inhibition of extracellular matrix mediated TGF-β signalling suppresses endometrial cancer metastasis.Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.In vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells.Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development.The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten
P2860
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P2860
Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.
description
2012 nî lūn-bûn
@nan
2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@ast
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@en
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@nl
type
label
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@ast
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@en
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@nl
prefLabel
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@ast
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@en
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1.
@nl
P2093
P2860
P3181
P1433
P1476
Stromal liver kinase B1 [STK11 ...... Target of Rapamycin Complex 1
@en
P2093
Christopher P Crum
Lihua Zhang
Pradeep S Tanwar
Yoshihiro Tanaka
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1002906
P577
2012-08-16T00:00:00Z