S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway - Wikidata - wikimedia - TriplyDB

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

http://www.wikidata.org/entity/Q24603083

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The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCepsilon, B-Raf and S6K2 Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase Signaling by target of rapamycin proteins in cell growth control Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells An emerging role for TOR signaling in mammalian tissue and stem cell physiology Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1 mTOR signaling: at the crossroads of plasticity, memory and disease Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway Ribosomal Protein S6 Phosphorylation in the Nervous System: From Regulation to Function Neuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathways Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae.Natural history of β-cell adaptation and failure in type 2 diabetes p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling mTOR signaling in tumorigenesis Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid Vitamin C and E supplementation alters protein signalling after a strength training session, but not muscle growth during 10 weeks of training Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit Striatal cholinergic interneurons display activity-related phosphorylation of ribosomal protein S6 Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response The p70S6K Specific Inhibitor PF-4708671 Impedes Non-Small Cell Lung Cancer Growth Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury Global and gene-specific translational regulation in rat lung development Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.Metabolic control by S6 kinases depends on dietary lipids Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.The mechanism of eukaryotic translation initiation and principles of its regulation

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P2860

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

http://www.wikidata.org/entity/Q24603083

description

2004 nî lūn-bûn

@nan

2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2004年の論文

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2004年論文

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2004年論文

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2004年論文

@zh-hk

2004年論文

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2004年論文

@zh-tw

2004年论文

@wuu

name

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@ast

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@en

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@nl

type

label

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@ast

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@en

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@nl

prefLabel

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@ast

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@en

S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@nl

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MCB.24.8.3112-3124.2004

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Molecular and Cellular Biology

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S6K1(-/-)/S6K2(-/-) mice exhib ...... se-dependent S6 kinase pathway

@en

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Jurgen Mestan

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Mario Pende

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Matthias Mueller

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Melanie Sticker

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Sara C Kozma

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Stefano Fumagalli

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Sung Hee Um

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Valerie L Goss

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P2860

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

Phosphorylation and activation of p70s6k by PDK1

The protein kinase complement of the human genome

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

Protein kinase C phosphorylates ribosomal protein S6 kinase betaII and regulates its subcellular localization.

Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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3112-24

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2930696

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10.1128/MCB.24.8.3112-3124.2004

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8

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24

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Virginie Mieulet

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2004-04-01T00:00:00Z

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15060135

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381608

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