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Activation of MDA5 requires higher-order RNA structures generated during virus infectionA crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesDeadenylation is a widespread effect of miRNA regulationAicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunityFull Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, BrazilTarget-specific requirements for enhancers of decapping in miRNA-mediated gene silencing.Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila.RIG-I detects viral genomic RNA during negative-strand RNA virus infection.Mouse knockout models for HIV-1 restriction factors.The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alpha.Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphatesNonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decayMicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay.Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses.mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1.Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.Exposing viruses: RNA patterns sensed by RIG-I-like receptors.Targeting the viral Achilles' heel: recognition of 5'-triphosphate RNA in innate anti-viral defence.RNA degradation in antiviral immunity and autoimmunityPurification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.SAMHD1-dependent retroviral control and escape in mice.Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence.Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.Is anti-viral defence the evolutionary origin of mRNA turnover? (Comment on DOI 10.1002/bies.201600100).Viruses transfer the antiviral second messenger cGAMP between cells.Keeping your armour intact: how HIV-1 evades detection by the innate immune system: HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS.Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.RNA sensing: the more RIG-I the merrier?Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.B Cells Producing Type I Interferon Modulate Macrophage Polarization in Tuberculosis.Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture.RECONsidering Sensing of Cyclic Dinucleotides.Infection with a Brazilian isolate of Zika virus generates RIG-I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling.
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hulumtues
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հետազոտող
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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Jan Rehwinkel
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P106
P21
P31
P496
0000-0003-3841-835X