Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.
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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytesMutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.An Integrated Genetic-Genomic Approach for the Identification of Novel Cancer Loci in Mice Sensitized to c-Myc-Induced Apoptosis.Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.Regulation and Function of the RasGRP Family of Ras Activators in Blood CellsInsertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.Cell of origin strongly influences genetic selection in a mouse model of T-ALLA Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signalingDiacylglycerol kinases: regulated controllers of T cell activation, function, and development.Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.RasGRP Ras guanine nucleotide exchange factors in cancer.G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesisRasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines.Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycleRegulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane.
P2860
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P2860
Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Deregulated expression of RasG ...... pendently of T-cell receptors.
@ast
Deregulated expression of RasG ...... pendently of T-cell receptors.
@en
Deregulated expression of RasG ...... pendently of T-cell receptors.
@nl
type
label
Deregulated expression of RasG ...... pendently of T-cell receptors.
@ast
Deregulated expression of RasG ...... pendently of T-cell receptors.
@en
Deregulated expression of RasG ...... pendently of T-cell receptors.
@nl
prefLabel
Deregulated expression of RasG ...... pendently of T-cell receptors.
@ast
Deregulated expression of RasG ...... pendently of T-cell receptors.
@en
Deregulated expression of RasG ...... pendently of T-cell receptors.
@nl
P2093
P2860
P356
P1433
P1476
Deregulated expression of RasG ...... pendently of T-cell receptors.
@en
P2093
Benoit Guilbault
Mark B Klinger
Rebecca E Goulding
Robert J Kay
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208334
P407
P577
2005-04-01T00:00:00Z
P5875
P6179
1052122226