The BRC repeats are conserved in mammalian BRCA2 proteins.
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityInteraction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammalsExpression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint controlBRCA2 and homologous recombinationPurified human BRCA2 stimulates RAD51-mediated recombinationCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairValine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatmentRec2 interplay with both Brh2 and Rad51 balances recombinational repair in Ustilago maydisBRCA1 and BRCA2 proteins: roles in health and diseaseTrypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombinationThe BRCA2 gene product functionally interacts with p53 and RAD51Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafishHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsAnalysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signalsInhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2Unraveling the mechanism of BRCA2 in homologous recombinationRAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinityCharacterizing a rat Brca2 knockout modelTumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutationCharacterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study.Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancerA monograph proposing the use of canine mammary tumours as a model for the study of hereditary breast cancer susceptibility genes in humansThe breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?Design of potent inhibitors of human RAD51 recombinase based on BRC motifs of BRCA2 protein: modeling and experimental validation of a chimera peptide.Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response.The pathology of familial breast cancer: How do the functions of BRCA1 and BRCA2 relate to breast tumour pathology?BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 geneCancer suppression by the chromosome custodians, BRCA1 and BRCA2.Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletionsEffects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3Structure and mechanism of action of the BRCA2 breast cancer tumor suppressorClinical management of women with genomic BRCA1 and BRCA2 mutations.Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms.Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene, BRCA2.
P2860
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P2860
The BRC repeats are conserved in mammalian BRCA2 proteins.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The BRC repeats are conserved in mammalian BRCA2 proteins.
@ast
The BRC repeats are conserved in mammalian BRCA2 proteins.
@en
The BRC repeats are conserved in mammalian BRCA2 proteins.
@nl
type
label
The BRC repeats are conserved in mammalian BRCA2 proteins.
@ast
The BRC repeats are conserved in mammalian BRCA2 proteins.
@en
The BRC repeats are conserved in mammalian BRCA2 proteins.
@nl
prefLabel
The BRC repeats are conserved in mammalian BRCA2 proteins.
@ast
The BRC repeats are conserved in mammalian BRCA2 proteins.
@en
The BRC repeats are conserved in mammalian BRCA2 proteins.
@nl
P50
P356
P1476
The BRC repeats are conserved in mammalian BRCA2 proteins.
@en
P2093
P356
10.1093/HMG/6.1.53
P577
1997-01-01T00:00:00Z