The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. - Wikidata - wikimedia - TriplyDB

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

http://www.wikidata.org/entity/Q34421358

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M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6 Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning Signaling by target of rapamycin proteins in cell growth control Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity Rheb and mTOR regulate neuronal polarity through Rap1B Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling Regulation of mTORC1 by PI3K signaling Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome Structural basis for the unique biological function of small GTPase RHEB Rig is a novel Ras-related protein and potential neural tumor suppressor Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling Human RAS superfamily proteins and related GTPases.Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.Ribosomal protein S6 kinase is a critical downstream effector of the target of rapamycin complex 1 for long-term facilitation in Aplysia.Recent progress in the study of the Rheb family GTPases.Rheb promotes cell growth as a component of the insulin/TOR signalling network.Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) ac Lipid posttranslational modifications. Farnesyl transferase inhibitors.Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb.Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis.Genetic networks in the mouse retina: growth associated protein 43 and phosphatase tensin homolog network.Mouse models of tuberous sclerosis complex.The tuberous sclerosis complex genes in tumor development.Expressional Difference of RHEB, HDAC1, and WEE1 Proteins in the Stromal Tumors of the Breast and Their Significance in Tumorigenesis.Tumorigenic activity and therapeutic inhibition of Rheb GTPase.Constitutively active Rheb induces oncogenic transformation.Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma.Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents.Mechanisms of Chromosome Congression during Mitosis.Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.Analysis of Rheb in the cellular slime mold Dictyostelium discoideum: cellular localization, spatial expression and overexpression.Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets.Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells Rheb GTPase regulates β-secretase levels and amyloid β generation

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P2860

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

http://www.wikidata.org/entity/Q34421358

description

1997 nî lūn-bûn

@nan

1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

1997年の論文

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1997年論文

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1997年論文

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1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

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name

The Ras-related protein Rheb i ...... signaling and transformation.

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The Ras-related protein Rheb i ...... signaling and transformation.

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The Ras-related protein Rheb i ...... signaling and transformation.

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type

label

The Ras-related protein Rheb i ...... signaling and transformation.

@ast

The Ras-related protein Rheb i ...... signaling and transformation.

@en

The Ras-related protein Rheb i ...... signaling and transformation.

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prefLabel

The Ras-related protein Rheb i ...... signaling and transformation.

@ast

The Ras-related protein Rheb i ...... signaling and transformation.

@en

The Ras-related protein Rheb i ...... signaling and transformation.

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Journal of Biological Chemistry

P1476

The Ras-related protein Rheb i ...... s signaling and transformation

@en

P2093

A D Hamilton

http://www.w3.org/2001/XMLSchema#string

C J Der

http://www.w3.org/2001/XMLSchema#string

G J Clark

http://www.w3.org/2001/XMLSchema#string

K Rogers-Graham

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S M Sebti

http://www.w3.org/2001/XMLSchema#string

P2860

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation

A ras-related gene with transformation suppressor activity

Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

A human oncogene of the RAS superfamily unmasked by expression cDNA cloning

Microinjection of recombinant p21rho induces rapid changes in cell morphology

The GTPase superfamily: conserved structure and molecular mechanism

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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10608-10615

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scholarly article

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16

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272

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Michael S. Kinch

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14117024

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