Rheb promotes cell growth as a component of the insulin/TOR signalling network.
about
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4EIdentification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6KUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaSignaling by target of rapamycin proteins in cell growth controlRegulation of mTOR and cell growth in response to energy stress by REDD1.Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylationRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexBiochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activityDisruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell developmentSpatial regulation of the mTORC1 system in amino acids sensing pathwaymTOR: from growth signal integration to cancer, diabetes and ageingThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machineryRheb and mTOR regulate neuronal polarity through Rap1BAbnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signalingIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlThe Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingHuman Cytomegalovirus Strategies to Maintain and Promote mRNA TranslationRegulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane TargetingOrgan Size Control: Lessons from DrosophilaLeucine and mTORC1: a complex relationshipRegulation of mTORC1 by PI3K signalingNutrient-sensing mechanisms across evolutionNutrient sensing, metabolism, and cell growth controlRegulation of mTORC1 by amino acidsNutritional regulation of stem and progenitor cells in DrosophilaMechanisms of TSC-mediated control of synapse assembly and axon guidanceCyclin G Functions as a Positive Regulator of Growth and Metabolism in DrosophilaTIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growthThe Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycinInsulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in DrosophilaThe Drosophila gene RanBPM functions in the mushroom body to regulate larval behavior.Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer YorkiemTOR kinase structure, mechanism and regulationStructure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)Rag proteins regulate amino-acid-induced mTORC1 signalling.Transcriptional and epigenetic regulation of autophagy in agingThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
P2860
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P2860
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@ast
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@en
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@nl
type
label
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@ast
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@en
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@nl
prefLabel
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@ast
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@en
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@nl
P2093
P2860
P356
P1433
P1476
Rheb promotes cell growth as a component of the insulin/TOR signalling network.
@en
P2093
Bruce A Edgar
Dominic A Chiarelli
Duoija Pan
Leslie J Saucedo
Xinsheng Gao
P2860
P2888
P304
P356
10.1038/NCB996
P577
2003-06-01T00:00:00Z
P5875
P6179
1027369198