ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. - Wikidata - wikimedia - TriplyDB

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.

http://www.wikidata.org/entity/Q34424253

about

Fisetin: a dietary antioxidant for health promotion Exploring the Validity of Valproic Acid Animal Model of Autism Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease.Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells.Lack of synergistic effect of resveratrol and sigma-1 receptor agonist (PRE-084) in SOD1G⁹³A ALS mice: overlapping effects or limited therapeutic opportunity?The stress response factor daf-16/FOXO is required for multiple compound families to prolong the function of neurons with Huntington's disease Back to the future with phenotypic screening ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment.HDL and cognition in neurodegenerative disorders.The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.Promise of resveratrol for easing status epilepticus and epilepsy.Resveratrol inhibits Cdk5 activity through regulation of p35 expression Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives Cell and brain tissue imaging of the flavonoid fisetin using label-free two-photon microscopy.Drosophila models of proteinopathies: the little fly that could.VGF and striatal cell damage in in vitro and in vivo models of Huntington's disease.Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103 Systemic regulation of mammalian ageing and longevity by brain sirtuins.The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling.Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease Targeting sirtuin-1 in Huntington's disease: rationale and current status.A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity.Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia.Resveratrol improves motoneuron function and extends survival in SOD1(G93A) ALS mice.Molecular biomarkers of lung carcinoma.

P2860

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P2860

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.

http://www.wikidata.org/entity/Q34424253

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

@wuu

name

ERK activation by the polyphen ...... odels of Huntington's disease.

@ast

ERK activation by the polyphen ...... odels of Huntington's disease.

@en

ERK activation by the polyphen ...... odels of Huntington's disease.

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type

label

ERK activation by the polyphen ...... odels of Huntington's disease.

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ERK activation by the polyphen ...... odels of Huntington's disease.

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ERK activation by the polyphen ...... odels of Huntington's disease.

@nl

prefLabel

ERK activation by the polyphen ...... odels of Huntington's disease.

@ast

ERK activation by the polyphen ...... odels of Huntington's disease.

@en

ERK activation by the polyphen ...... odels of Huntington's disease.

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Human Molecular Genetics

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ERK activation by the polyphen ...... odels of Huntington's disease.

@en

P2093

J Lawrence Marsh

http://www.w3.org/2001/XMLSchema#string

Judith M Purcell

http://www.w3.org/2001/XMLSchema#string

Laszlo Bodai

http://www.w3.org/2001/XMLSchema#string

Pamela Maher

http://www.w3.org/2001/XMLSchema#string

Paul E Gerard

http://www.w3.org/2001/XMLSchema#string

Richard Dargusch

http://www.w3.org/2001/XMLSchema#string

P2860

SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells

Mechanism of human SIRT1 activation by resveratrol

Can flies help humans treat neurodegenerative diseases?

Resveratrol is not a direct activator of SIRT1 enzyme activity

Substrate-specific activation of sirtuins by resveratrol

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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261-270

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10.1093/HMG/DDQ460

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2

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20

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2010-10-15T00:00:00Z

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47449728

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20952447

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Huntington disease

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3005900

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