RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. - Wikidata - wikimedia - TriplyDB

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.

http://www.wikidata.org/entity/Q34425705

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Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma.Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families Hereditary breast cancer: ever more pieces to the polygenic puzzle.Variations in the NBN/NBS1 gene and the risk of breast cancer in non-BRCA1/2 French Canadian families with high risk of breast cancer Mutation analysis of the AATF gene in breast cancer families.Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility.RAD50 targeting impairs DNA damage response and sensitizes human breast cancer cells to cisplatin therapy Breast cancer susceptibility: current knowledge and implications for genetic counselling Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome.Lymphocyte telomere length is long in BRCA1 and BRCA2 mutation carriers regardless of cancer-affected status.The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Mutation inactivation of Nijmegen breakage syndrome gene (NBS1) in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.Growing recognition of the role for rare missense substitutions in breast cancer susceptibility The redox biology network in cancer pathophysiology and therapeutics Targeted Next-Generation Sequencing Identifies a Recurrent Mutation in MCPH1 Associating with Hereditary Breast Cancer Susceptibility.INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells Clinical Application of Multigene Panels: Challenges of Next-Generation Counseling and Cancer Risk Management.Mutation screening of RAD51C in high-risk breast and ovarian cancer families.Gene-panel sequencing and the prediction of breast-cancer risk.Mechanisms of BRCA1 tumor suppression Association of the nibrin gene (NBN) variants with breast cancer.Network-based global inference of human disease genes A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function Hereditary breast cancer in the Han Chinese population.Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients.Molecular genetics of breast and ovarian cancer: recent advances and clinical implications Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy Heterozygous mutations in PALB2 cause DNA replication and damage response defects.The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers.Update on genetic predisposition to breast cancer.Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.Exome Sequencing in a Family with Luminal-Type Breast Cancer Underpinned by Variation in the Methylation Pathway.

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RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability.

http://www.wikidata.org/entity/Q34425705

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@ast

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@en

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@nl

type

label

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@ast

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@en

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@nl

prefLabel

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@ast

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@en

RAD50 and NBS1 are breast canc ...... ated with genomic instability.

@nl

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RAD50 and NBS1 are breast canc ...... ated with genomic instability.

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Ake Borg

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Hannele Erkko

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John Petrini

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Katri Heikkinen

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Katrin Rapakko

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Rosa B Barkardottir

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Sakari Knuutila

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Sanna-Maria Karppinen

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Tuija Lundán

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P2860

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis

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1593-1599

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10.1093/CARCIN/BGI360

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8

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27

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Anne-Lise Børresen-Dale

Robert Winqvist

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7302865

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16474176

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