Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. - Wikidata - wikimedia - TriplyDB

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

http://www.wikidata.org/entity/Q34427548

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Nijmegen breakage syndrome (NBS)A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin ATM activation by ionizing radiation requires BRCA1-associated BAAT1 ATMIN defines an NBS1-independent pathway of ATM signalling Modeling the study of DNA damage responses in mice Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair The response to and repair of RAG-mediated DNA double-strand breaks Fertility defects revealing germline biallelic nonsense NBN mutations DNA damage response genes and the development of cancer metastasis NBS1, the Nijmegen breakage syndrome gene product, regulates neuronal proliferation and differentiation NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.Recruitment of DNA damage checkpoint proteins to damage in transcribed and nontranscribed sequences.BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection.Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia.Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes.Modeling the role of p53 pulses in DNA damage- induced cell death decision.AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.CtIP-mediated resection is essential for viability and can operate independently of BRCA1.The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.The MRN complex in double-strand break repair and telomere maintenance.DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism Time to bloom.ATM signalling and cancer.DNA double-strand break signaling and human disorders.Loss of ATM kinase activity leads to embryonic lethality in mice Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase.Active role for nibrin in the kinetics of atm activation Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes.ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.

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P2860

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

http://www.wikidata.org/entity/Q34427548

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@ast

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@en

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

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type

label

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@ast

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@en

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@nl

prefLabel

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@ast

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@en

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@nl

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Nature Cell Biology

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Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

@en

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André Nussenzweig

http://www.w3.org/2001/XMLSchema#string

Arkady Celeste

http://www.w3.org/2001/XMLSchema#string

Bernardo Reina San Martin

http://www.w3.org/2001/XMLSchema#string

Francois Van Laethem

http://www.w3.org/2001/XMLSchema#string

Galina V Petukhova

http://www.w3.org/2001/XMLSchema#string

Hua-Tang Chen

http://www.w3.org/2001/XMLSchema#string

Katia Manova

http://www.w3.org/2001/XMLSchema#string

Lionel Feigenbaum

http://www.w3.org/2001/XMLSchema#string

Michael Eckhaus

http://www.w3.org/2001/XMLSchema#string

Michael Kruhlak

http://www.w3.org/2001/XMLSchema#string

P2860

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Chk2 activation dependence on Nbs1 after DNA damage

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Immunoglobulin class switch recombination is impaired in Atm-deficient mice

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair.

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P304

675-685

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scholarly article

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10.1038/NCB1270

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7

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P478

7

http://www.w3.org/2001/XMLSchema#string

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Michel C. Nussenzweig

P577

2005-06-19T00:00:00Z

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1025699748

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15965469

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