Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. - Wikidata - wikimedia - TriplyDB

Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

http://www.wikidata.org/entity/Q34433399

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Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations Minireview: Nutrient sensing by G protein-coupled receptors Kokumi substances, enhancers of basic tastes, induce responses in calcium-sensing receptor expressing taste cells Metabolism-guided design of short-acting calcium-sensing receptor antagonists.Discovery of a potent and short-acting oral calcilytic with a pulsatile secretion of parathyroid hormone Physiology and pathophysiology of the calcium-sensing receptor in the kidney Update in new anabolic therapies for osteoporosis Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia.Inhibition of the Ca(2+)-sensing receptor rescues pulmonary hypertension in rats and mice.Novel calcium sensing receptor ligands: a patent survey.Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis.Extracellular calcium-sensing receptor: structural and functional features and association with diseases.Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.Pharmacodynamic model of parathyroid hormone modulation by a negative allosteric modulator of the calcium-sensing receptor Novel treatments for osteoporosis.Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.New concepts in calcium-sensing receptor pharmacology and signalling Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives New treatment modalities in osteoporosis.The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).The calcium-sensing receptor in normal physiology and pathophysiology: a review.Emerging and potential therapies for osteoporosis.PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.Osteoporosis: now and the future Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.Anabolic skeletal therapy for osteoporosis.Dihydropyridine Ca(2+) channel blockers increase cytosolic [Ca(2+)] by activating Ca(2+)-sensing receptors in pulmonary arterial smooth muscle cells Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders.Emerging pharmacologic therapies for osteoporosis.Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension.Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy.The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion.The osteoporosis revolution marches on.The role of the calcium-sensing receptor in bone biology and pathophysiology Disorders of phosphate homeostasis and tissue mineralisation.FGF23 and syndromes of abnormal renal phosphate handling Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.Bone biology and anabolic therapies for bone: current status and future prospects.

P2860

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P2860

Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats.

http://www.wikidata.org/entity/Q34433399

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2000 nî lūn-bûn

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P2860

Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs

Calcimimetics with potent and selective activity on the parathyroid calcium receptor

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents.

Emerging insights into the role of calcium ions in osteoclast regulation.

Anabolic actions of parathyroid hormone on bone.

Parathyroid hormone treatment can reverse corticosteroid-induced osteoporosis. Results of a randomized controlled clinical trial.

Quantification of the collagenolytic activity of isolated osteoclasts by enzyme-linked immunosorbent assay.

Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity.

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